Title:
【発明の名称】抗生物クリプトジンペプチド及びその使用方法
Document Type and Number:
Japanese Patent JPH10509047
Kind Code:
A
Abstract:
The present invention provides substantially purified cryptdin peptides having a consensus amino acid sequence:wherein X1 is 3 to 9 amino acids; X2 is one amino acid, preferably Y, H or R; X3 is 2 or 3 amino acids; X4 is three amino acids; X5 is five amino acids; X6 is 6 to 10 amino acids; and X7 is 0 to 9 amino acids. The invention also provides a substantially purified mouse cryptdin having a consensus amino acid sequence:wherein X1 is 3 or 4 amino acids, preferably LRD, LSKK (SEQ ID NO: 1) or LRG; X2 is 1 amino acid, preferably V, L or I; X3 is 3 amino acids, preferably KGH or *RG, where * is S, T, K, I or A; X4 is 2 amino acids, preferably GR, RR or RG; X5 is 3 amino acids, preferably RMN, RVR, RVF HMN or HIN; X6 is 6 to 9 amino acids, preferably GIRFLY (SEQ ID NO: 2) or RNLFLTFVF (SEO ID NO: 3), RRGHLMYTL (SEQ ID NO: 4) or RKGHL*YT* (SEQ ID NO: 5), where * independently is L or M; and X7 is 0 to 3 amino acids, preferably R, S or PRR. The invention also provides cryptdin analogs, which are devoid of one or more amino acids N-terminal to the first cysteine. In addition, the invention provides nucleic acid molecules encoding cryptdin peptides. The invention further provides methods for detecting inflammatory pathologies in a subject and for treating an inflammatory pathology in a subject by administering a pharmaceutical composition containing a cryptdin peptide.
Inventors:
Selstead, Michael E.
Owellette, Andre Jay.
Owellette, Andre Jay.
Application Number:
JP51683996A
Publication Date:
September 08, 1998
Filing Date:
October 05, 1995
Export Citation:
Assignee:
The Regents of the University of California
The Shriners Hospital for Cripple Children
The Shriners Hospital for Cripple Children
International Classes:
A61K9/22; A61K38/00; A61K39/395; A61P1/00; A61P29/00; C12P21/08; C07K14/46; C07K14/47; C07K16/18; C12N15/09; C12Q1/68; G01N33/564; G01N33/569; G01N33/68; (IPC1-7): C12N15/09; A61K38/00; C07K14/47; C07K16/18; C12Q1/68
Attorney, Agent or Firm:
Atsushi Nakajima (2 outside)