Title:
【発明の名称】クロメン-3-カルボン酸誘導体
Document Type and Number:
Japanese Patent JP3076066
Kind Code:
B2
Abstract:
The present invention provides a compound of the formula (I): wherein R<1>, R<2>, R<3> and R<4> are each independently hydrogen, optionally substituted alkyl, hydroxy, optionally substituted alkoxy or the like, R<5> is optionally substituted alkyl, optionally substituted aryl, optionally substituted heterocyclic or the like, R<6> is hydrogen, optionally substituted alkyl or the like, R<7> is hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, optionally substituted heterocyclic or the like, A is S or O and a broken line represents presence or absence of a bond, pharmaceutically acceptable salt or hydrate thereof and a pharmaceutical composition or a pharmaceutical composition for use as an endothelin receptor antagonist, a peripheral circulation insufficiency-improving agent or a macrophage foam cell formation inhibitor comprising the compound.
Inventors:
Natsuki Ishizuka
Kenichi Matsumura
Katsunori Sakai
Toshiro Konoike
Tadahiko Yorifuji
Harujiro Hara
Yoshiyuki Matsuo
Kenichi Matsumura
Katsunori Sakai
Toshiro Konoike
Tadahiko Yorifuji
Harujiro Hara
Yoshiyuki Matsuo
Application Number:
JP50269898A
Publication Date:
August 14, 2000
Filing Date:
August 22, 1997
Export Citation:
Assignee:
Shionogi Pharmaceutical Co., Ltd.
International Classes:
C07D311/60; C07D407/04; C07D407/14; C07D409/04; C07D409/14; C07D311/22; (IPC1-7): C07D311/22; A61K31/00; A61K31/352; A61K31/382; A61P9/00; A61P43/00; C07D311/58; C07D311/60; C07D311/64; C07D311/68; C07D335/06; C07D407/04; C07D407/12; C07D409/04; C07D417/14
Attorney, Agent or Firm:
Hideaki Yamauchi