Title:
【発明の名称】あるメタノ架橋キノリジン類のアミド類似体類の誘導体類
Document Type and Number:
Japanese Patent JP3377227
Kind Code:
B2
Abstract:
This invention relates to derivatives of formula wherein A is =H2, =O, =(H) (OH), NOR1, or with n being 2 or 3, X and Y are O or S, R1 is H or alkyl, R2 is H, halogeno, alkyl, alkoxy, OH, -CN or C(O)NH2, Z is O, S or NR1, Q is a heterocyclic or carbocyclic moiety of the formulae to the intermediates and processes for their preparation, to their ability to induce a blockage of 5HT3 receptors, and to their end-use application in the treatment of chemotherapeutically-induced nausea and vomiting, as anti-anxiety agents, in the symptomatic treatment of pain associated with migraine, as anti-arrhythmic agents, in the treatment of cognitive disorders, in treating hallucinatory endogenous psychoses of the type manifested in patients suffering from schizophrenia, and mania, in the treatment of glaucoma and for stimulating gastric motility, and to combat drug abuse.
Inventors:
Morris Words
Application Number:
JP17598392A
Publication Date:
February 17, 2003
Filing Date:
June 11, 1992
Export Citation:
Assignee:
Merrell Fa-Mass-Tikal's Parakeet-Polated
International Classes:
A61K31/439; A61P1/08; A61P1/12; A61P9/06; A61P11/16; A61P25/04; A61P25/06; A61P25/18; A61P25/20; A61P25/24; A61P25/28; A61P25/30; A61P27/06; C07D471/18; C07D491/147; A61K31/435; C07D491/22; C07D495/10; C07D495/22; C07D497/10; C07D519/00; (IPC1-7): C07D471/18
Domestic Patent References:
| JP1268634A |
Attorney, Agent or Firm:
Katsuro Sasai