Title:
【発明の名称】ジエチレントリアミンペンタ酢酸-モノアミド及びその錯体及び錯塩、その製法、これを含有するNMR-、レントゲン-及び放射線-診断剤並びに放射線-又は射線療法剤及びその薬剤の製法
Document Type and Number:
Japanese Patent JP2854159
Kind Code:
B2
Abstract:
Compounds of the general formula I in which Z<1> and Z<2> in each case represent a hydrogen atom or the radical -(CH2)m-(C6H4)q-(O)k-(CH2)n-(C6H4)l-(O)r-R, in which m and n denote the figures 0-20, k, l, q and r denote the figures 0 and 1 and R denotes a hydrogen atom, an optionally OR<1>-substituted C1-C6-alkyl radical or a CH2COOR<1> group where R<1> denotes a hydrogen atom, a C1-C6-alkyl radical or a benzyl group, R<2> represents a saturated, unsaturated, straight- or branched-chain or cyclic alkyl group having up to 20 C atoms, aryl group or aralkyl group substituted by a carboxyl group optionally esterified with a C1-C6-alkyl or benzyl radical, or by a sulphone group, R<3> represents a hydrogen atom or a saturated, unsaturated, straight- or branched-chain or cyclic alkyl group having up to 20 C atoms, aryl group or aralkyl group optionally substituted by a carboxyl group which is optionally esterified with a C1-C6-alkyl or benzyl radical, or by a sulphone group, X represents a hydrogen atom and/or a metal ion equivalent of an element of atomic number 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, with the proviso that at least one of the substituents Z<1> and Z<2> represents a hydrogen atom, that - when n and l each represent the figure 0 - k and r do not simultaneously each denote the figure 1 and that, if desired, the radical of the acid groups is present as an ester or amide, and their salts with inorganic and/or organic bases, amino acids or amino acid amides, are useful pharmaceutical agents.y
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Inventors:
HAINTSU GURIISU
EERITSUHI KURIIGAA
BERUNTO RADEYUUHIERU
HERIBERUTO SHUMITSUTOOIRITSUHI
HANSUUYOAHIMU UAINMAN
FUUBERUTO FUOKURAA
GABURIERE SHUUMANNGIAMUPIERI
YURUGEN KONRATSUTO
EERITSUHI KURIIGAA
BERUNTO RADEYUUHIERU
HERIBERUTO SHUMITSUTOOIRITSUHI
HANSUUYOAHIMU UAINMAN
FUUBERUTO FUOKURAA
GABURIERE SHUUMANNGIAMUPIERI
YURUGEN KONRATSUTO
Application Number:
JP9797691A
Publication Date:
February 03, 1999
Filing Date:
April 04, 1991
Export Citation:
Assignee:
SHEERINGU AG
International Classes:
A61K49/04; A61K49/06; C07C237/04; C07C237/06; C07C237/12; C07C309/15; A61K49/00; C07C309/51; C07C323/41; C07C323/42; C07D265/32; C07F5/00; C07F15/02; (IPC1-7): C07C237/06; A61K49/00; C07C237/12; C07C323/41; C07C323/42; C07D265/32
Domestic Patent References:
| JP4500964A | ||||
| JP3215457A | ||||
| JP3173856A | ||||
| JP2502820A | ||||
| JP6393758A |
Attorney, Agent or Firm:
Toshio Yano (2 outside)