Title:
【発明の名称】新生物の治療のためのフォ-レ-ト及びアンチフォ-レ-トとのジフルオログルタミン酸のコンジュゲ-ト類
Document Type and Number:
Japanese Patent JP2894576
Kind Code:
B2
Abstract:
This invention relates to certain conjugates of folates and antifolates with difluoroglutamic acid which are useful in the treatment of patients suffering from certain neoplastic diseases including leukemia, melanomas, carcinomas, sarcomas and mixed neoplasias.
Inventors:
FUIRITSUPE BEI
JEIMUZU KEI KOWAADO
JON JEI MAKUGAIAA
JEIMUZU KEI KOWAADO
JON JEI MAKUGAIAA
Application Number:
JP10638991A
Publication Date:
May 24, 1999
Filing Date:
April 12, 1991
Export Citation:
Assignee:
HERUSU RISAACHI INC
MERERU PHARM INC
YUNIBAASHITEI OBU MISHIGAN ZA
MERERU PHARM INC
YUNIBAASHITEI OBU MISHIGAN ZA
International Classes:
A61K31/517; A61K31/519; A61P35/00; A61P35/02; C07D239/88; C07D239/90; C07D239/94; C07D239/95; A61K31/505; C07D471/04; C07D475/08; (IPC1-7): C07D239/88; A61K31/505; C07D239/90; C07D239/94; C07D239/95; C07D471/04; C07D475/08
Domestic Patent References:
| JP4235144A |
Other References:
”ＡＣＳ Ｓｙｍｐ．Ｓｅｒ．”，第４５６号，ｐ．１９６−２０４，１９９１年
”Ｊ．Ｂｉｏｌ．Ｃｈｅｍ．”，第２６５巻，第２４号，１４０７３−１４０７９，１９９０年
”Ｊ．Ｂｉｏｌ．Ｃｈｅｍ．”，第２６５巻，第２４号，１４０７３−１４０７９，１９９０年
Attorney, Agent or Firm:
Katsuro Sasai