Title:
【発明の名称】低脂血症性化合物1,4-チアゼピン
Document Type and Number:
Japanese Patent JPH08507049
Kind Code:
A
Abstract:
PCT No. PCT/GB94/00299 Sec. 371 Date Aug. 15, 1995 Sec. 102(e) Date Aug. 15, 1995 PCT Filed Feb. 15, 1994 PCT Pub. No. WO94/18183 PCT Pub. Date Aug. 18, 1994The invention provides a compound of formula (I), wherein n is an integer of from 0 to 2; R is an optional substituent; R1 is hydrogen or C1-6alkyl; R2 is an atom or group selected from hydrogen, C1-4alkyl (including cycloalkyl and cycloalkylalkyl), C1-4alkoxy, pyrryl, thienyl, pyridyl, 1,3-benzodioxolo, phenyl and naphthyl, which groups are optionally substituted; R3 is hydrogen, OH, C1-6alkyl, C1-6alkoxy or -O C1-6acyl; R4 is a group independently selected from C1-6alkyl (including cycloalkyl and cycloalkylalkyl), C2-6alkenyl, and C2-6-alkynyl which groups are optionally substituted; R5 is a group independently selected from C2-6alkyl (including cycloalkyl and cycloalkylalkyl), C2-6alkenyl and C2-6alkynyl, which groups are optionally substituted; or R4 and R5, together with the carbon atom to which they are attached, form a C3-7spiro cycloalkyl group which is optionally substituted; R6 and R7 are independently selected from hydrogen and C1-6alkyl; and X is an aromatic or non-aromatic monocyclic or bicyclic ring system having from 5 to 10 carbon atoms (including the two carbon atoms forming part of the thiazepine ring) wherein optionally one or more of the carbon atoms is/are replaced by heteroatom(s) independently selected from nitrogen, oxygen and sulphur, or X is an aromatic or non-aromatic monocyclic or bicyclic ring system having from 5 to 10 carbon atoms (including the two carbon atoms forming part of the thiazepine ring) wherein one or more of the carbon atoms is/are replaced by heteroatom(s) independently selected from nitrogen, oxygen and sulphur; and salts, solvates and physiologically functional derivatives thereof, pharmaceutical formulations comprising such compounds, processes for their preparation and their use in reducing bile acid uptake and hence as hypolipidaemic compounds. (I)
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Inventors:
Bree Adie, Lawrence Edward
Hodgson, Gordon Lewis Jr.
Hodgson, Gordon Lewis Jr.
Application Number:
JP51784494A
Publication Date:
July 30, 1996
Filing Date:
February 15, 1994
Export Citation:
Assignee:
The Welcome Foundation Limited
International Classes:
A61K31/55; A61K31/554; A61P3/06; A61P9/10; C07D281/08; C07D281/10; C07D285/10; C07D417/04; C07D513/04; (IPC1-7): C07D281/08; A61K31/55; C07D281/10; C07D285/10; C07D417/04; C07D513/04
Attorney, Agent or Firm:
Takehiko Suzue (3 outside)