Title:
【発明の名称】複合骨移植片の調製方法
Document Type and Number:
Japanese Patent JP2001502561
Kind Code:
A
Abstract:
A kit for preparing an implantable graft, particularly an implantable, composite bone graft is provided. The kit includes a porous, biocompatible, sterile substrate and a container configured to retain the substrate and to permit flow of a cell suspension, particularly a bone marrow aspirate suspension therethrough. A method which employs such kit for preparing a composite implantable bone graft is also provided. The method includes the steps of providing a bone marrow aspirate suspension and passing the bone marrow aspirate suspension through a porous, biocompatible, implantable substrate to provide a composite bone graft having an enriched population of connective tissue progenitor cells. The composite bone graft prepared by the present method contains an enriched population of connective tissue progenitor cells and a greater number of connective tissue progenitor cells per unit volume than that found in the original bone marrow aspirate. The present invention also relates to a composite bone marrow graft prepared according to the present method.
Inventors:
Mushurer, George Frederick
Application Number:
JP50454098A
Publication Date:
February 27, 2001
Filing Date:
July 03, 1997
Export Citation:
Assignee:
The Cleveland ClinicFoundation
International Classes:
A61L27/00; A61F2/28; A61F2/38; A61F2/46; A61K39/40; A61L27/32; A61L27/36; A61L27/38; A61L27/48; A61L27/58; B01D15/08; A61F2/00; A61F2/30; (IPC1-7): A61L27/00; A61F2/38
Attorney, Agent or Firm:
Shusaku Yamamoto