Title:
【発明の名称】3,3-ビス-(4-ジメチルアミノフェニル)-6-ジメチルアミノフタリドの製造法
Document Type and Number:
Japanese Patent JP2784532
Kind Code:
B2
Abstract:
PURPOSE:To obtain the title dimethylaminophthalide improved in yields and quality by performing the oxidation of a specified benzoic acid derivative in the presence of a catalyst comprising iron, a manganese compound and a chelating agent. CONSTITUTION:The purpose 3,3-bis(4-dimethylaminophenyl)-6- dimethylaminophthalide is obtained by oxidizing 2-[4,4'-bis(dimethylamino) benzohydryl]-5-dimethylaminobenzoic acid of formula I in a basic aqueous solution of a pH of 7.0-14.0 in the presence of three catalysts of iron, a manganese compound and a chelating agent. Any basic compound such as a hydroxide or a carbonate of sodium or potassium or ammonia may be used to adjust the pH of the aqueous reaction solution to 7.0-14.0. The oxidation is usually performed at 50-100 deg.C, and it can be accomplished by introducing hydrogen peroxide, oxygen or an oxygen-containing gas as an oxidizing agent into the reaction solution under atmospheric or elevated pressure.
Inventors:
SHIMIZU YOJI
KAWAI HAJIME
TSUNEMITSU KATSUHIKO
KAWAI HAJIME
TSUNEMITSU KATSUHIKO
Application Number:
JP19870188A
Publication Date:
August 06, 1998
Filing Date:
August 08, 1988
Export Citation:
Assignee:
YAMADA KAGAKU KOGYO KK
International Classes:
C07D307/88; B01J31/22; C07B61/00; C09B11/00; C09B11/20; (IPC1-7): C09B11/00; B01J31/22
Domestic Patent References:
| JP62184061A | ||||
| JP5525496A | ||||
| JP50124931A | ||||
| JP4710632A |
Attorney, Agent or Firm:
Junichi Ando