Title:
【発明の名称】8α‐置換6‐メチル‐10α‐H‐エルゴリンの製法
Document Type and Number:
Japanese Patent JPH0631232
Kind Code:
B2
Abstract:
1. Process for the preparation of 8 alpha-substituted 6-methyl-10 alpha-H-ergolines of the general formula : see diagramm : EP0032684,P4,F1 in which R**1 is NH-CO-NR2 , CO-NH-NR2 , CONR2 or CH2 OR (wherein R in each case represents hydrogen, methyl or ethyl) by reduction of corresponding 8 alpha-substituted 9,10-didehydro-6-methylergolines with alkali-metal in liquid ammonia, characterised in that the reduction is carried out in the presence of an arylamine from the group aniline, methylaniline, anisidine, o-dianisidine, diphenylamine, ethylaniline, p-phenylenediamine, dimethoxyaniline, phenylhydrazine, dinitrophenylhydrazine and benzidine in an amount of 0.5-5 molar equivalents relative to the ergoline present.
Inventors:
GERUHARUTO ZAUAA
Application Number:
JP329981A
Publication Date:
April 27, 1994
Filing Date:
January 14, 1981
Export Citation:
Assignee:
SCHERING AG
International Classes:
A61K31/48; C07D457/02; C07D457/06; C07D457/12; (IPC1-7): C07D457/02; C07D457/06; C07D457/12
Domestic Patent References:
| JP4826799A |
Other References:
小方芳郎著「有機化合物の酸化と還元」（昭和３９−４−１）南江堂Ｐ．５６３〜Ｐ．５８０，Ｐ．６９７〜Ｐ．７１３ＣｈｅｍｉｃａｌＡｂｓｔｒａｃｔｓ，８４：４４５１７ｎ（１９７６）
Attorney, Agent or Firm:
Toshio Yano
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