Title:
【発明の名称】Nーアセチルー3ーフルオローノイラミン酸誘導体およびその製造方法
Document Type and Number:
Japanese Patent JP2573594
Kind Code:
B2
Abstract:
This invention relates to novel derivatives of N-acetyl-3-fluoro-neurminic acid derivatives (I) and preparation thereof. The compound (I) can be synthesized by reacting a solution of alkyl 5-acetamido-2,6-anhydro-4,7,8,9-tetra-O-acetyl-2,3,5-trideoxy-D-glycer o-D-galact o-2-enonate with (i) an inert gas containing fluorine or (ii) acetylhypofluorite obtained by passing the inert gas containing fluorine through a mixture of acetic acid/acetate by passing thereinto, and then removing a solvent and applying the residue through a silica gel column chromatography.
Inventors:
OORUI HIROSHI
MEGURO HIROMU
IDO TATSUO
MEGURO HIROMU
IDO TATSUO
Application Number:
JP5235887A
Publication Date:
January 22, 1997
Filing Date:
March 06, 1987
Export Citation:
Assignee:
KANTO ISHI PHARMA CO LTD
International Classes:
A61K31/70; A61K31/7024; C07H13/06; A61P31/12; A61P37/00; C07H7/027; C07H13/04; (IPC1-7): C07H13/06
Attorney, Agent or Firm:
Yamato Tsutsui (1 person outside)