Title:
【発明の名称】ピペラジニル誘導体
Document Type and Number:
Japanese Patent JPH06500546
Kind Code:
A
Abstract:
Piperazinyl derivatives of the general formula I (I) wherein R1 represents substituted phenyl, 1- or 2-diazanaphthyl, azadiazanaphtyl or diazanaphtyl groups; n is 1, 2, 3 or 4; X is -O- or wherein R2 is hydrogen, C1-6-alkyl or C3-8-cycloalkyl; Y is =O or =S or =NZ wherein Z is hydrogen, C1-6-alkyl or -CN and R3 is selected from a group consisting of various structures have been found to exhibit high affinity for various receptor subtypes including the 5-HT2 receptor, the 5-HT1A receptor, the alpha1 receptor the dopamine receptor or a combination of these and may therefore be useful for treating CNS system, cardiovascular system and gastrointestinal disorders.
Inventors:
Jeppesen loan
Christiansen Maritt
Hansen John Bond
Christiansen Maritt
Hansen John Bond
Application Number:
JP51432591A
Publication Date:
January 20, 1994
Filing Date:
August 23, 1991
Export Citation:
Assignee:
Novo Nordisk Actiesel Scab
International Classes:
A61P25/00; A61P25/04; A61P25/18; A61P25/24; A61P25/26; C07D215/40; C07D215/42; C07D277/62; A61K31/495; C07D277/82; C07D295/08; C07D295/084; C07D295/088; C07D295/13; C07D317/50; C07D317/66; C07D319/08; C07D319/18; C07D321/10; C07D405/12; C07D471/04; C07D; (IPC1-7): C07D277/82; A61K31/495; C07D215/42; C07D295/08; C07D317/50; C07D319/08; C07D321/10; C07D405/12; C07D471/04
Attorney, Agent or Firm:
Minoru Nakamura (6 outside)