Title:
【発明の名称】高血圧治療用ピペリジニル-末端化N-(ジヒドロキシアルキル)-エチニルアラニンアミド
Document Type and Number:
Japanese Patent JP3363448
Kind Code:
B2
Abstract:
Compounds characterized generally as piperidinyl-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of Formula I (* CHEMICAL STRUCTURE *) (I) wherein A is selected from CO and SO2; wherein X is selected from oxygen atom and methylene; wherein B is selected from a piperidinyl group, an isoindolyl group and an azabicyclononyl group; wherein R1 is selected from hydrido, methyl, ethyl, isopropyl and n-propyl; wherein R2 is phenylmethyl; wherein each of R3 and R5 is hydrido; wherein R4 is selected from (* CHEMICAL STRUCTURE *) wherein V is selected from hydrido and methyl; wherein R6 is cyclohexylmethyl; wherein R7 is selected from isobutyl, cyclopropyl and cyclopropylmethyl; wherein q is a number selected from zero through three, inclusive; and wherein n is a number selected from zero through three, inclusive; or a pharmaceutically-acceptable salt thereof.
Inventors:
Hanson, Gunner Jay.
Application Number:
JP50622194A
Publication Date:
January 08, 2003
Filing Date:
February 24, 1993
Export Citation:
Assignee:
G.D.Searle & Company
International Classes:
A61K31/395; A61K31/397; A61K31/40; A61K31/403; A61K31/4035; A61K31/435; A61K31/439; A61K31/44; A61K31/445; A61K31/4453; A61K31/45; A61K31/451; A61K31/47; A61K31/472; A61K31/55; A61P9/08; A61P9/10; A61P9/12; A61P13/02; A61P15/00; A61P27/02; A61P27/06; A61P43/00; C07D205/04; C07D209/44; C07D209/52; C07D211/14; C07D295/12; C07D211/26; C07D211/38; C07D211/70; C07D211/72; C07D211/74; C07D211/78; C07D215/06; C07D217/04; C07D221/06; C07D221/22; C07D221/26; C07D295/13; C07D451/02; C07D453/02; C07D453/06; C07D471/08; (IPC1-7): C07D205/04; A61K31/397; A61K31/40; A61K31/403; A61K31/4035; A61K31/435; A61K31/439; A61K31/44; A61K31/445; A61K31/4453; A61K31/45; A61K31/472; A61K31/55; A61P9/12; C07D209/44; C07D209/52; C07D211/26; C07D211/38; C07D211/70; C07D211/72; C07D217/04; C07D221/22; C07D221/26; C07D295/12; C07D451/02; C07D453/06; C07D471/08
Domestic Patent References:
| JP4279572A | ||||
| JP23646A | ||||
| JP3112957A | ||||
| JP3505583A | ||||
| JP1502514A |
Attorney, Agent or Firm:
Akira Asamura (3 outside)