Title:
【発明の名称】アロマターゼ阻害剤としてのピロロイミダゾリルおよびイミダゾピリジニル置換1H-ベンズイミダゾール誘導体
Document Type and Number:
Japanese Patent JPH07503242
Kind Code:
A
Abstract:
Pyrroloimidazolyl and imidazopyridinyl substituted 1H &cir& _-benzimidazole derivatives having formula (I) wherein n is 0 or 1; R<1> is hydrogen, nitro, amino, mono- or diC1-6alkyl)amino, halo, C1-6alkyl, hydroxy or C1-6alkyloxy; R<2> is hydrogen; C1-10alkyl; C3-6alkenyl; C3-6alkynyl; C3-7cycloalkyl; phenyl; substituted phenyl; C1-4alkyl substituted with phenyl, substituted phenyl, naphthalenyl, thienyl, furanyl, C1-4alkylfuranyl, C3-7cycloalkyl; and R<3> is hydrogen, C1-8alkyl; C3-7cycloalkyl; hydroxy, amino; C1-6alkyloxy; C1-6alkyloxycarbonylamino; phenyl; C1-4alkyl substituted with phenyl, piperazinyl, 4-(C1-4alkyl)piperazinyl or morpholinyl; each substituted phenyl independently is phenyl substituted with a substituent independently selected from halo, hydroxy, hydroxymethyl, trifluoromethyl, C1-6alkyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, formyl, (hydroxyimino)methyl, cyano, amino, mono- and di(C1-6alkyl)amino and nitro, having sex hormone synthesis inhibiting properties. Compositions containing said compounds of formula (I). Preparations of said compounds and compositions, and use thereof for treating mammals suffering from sex hormone disorders.
Inventors:
Marcell August Constant, Janssen
Ray Mekas, Alphonse Hermann Margareta
Freine, Eddie Gene Edgart
Greco, Michael Nicholas
Ray Mekas, Alphonse Hermann Margareta
Freine, Eddie Gene Edgart
Greco, Michael Nicholas
Application Number:
JP51290993A
Publication Date:
April 06, 1995
Filing Date:
January 20, 1993
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
A61K31/415; A61K31/435; C07D471/04; C07D487/04; (IPC1-7): C07D471/04; A61K31/415; A61K31/435; C07D487/04
Attorney, Agent or Firm:
Heiyoshi Odashima