Title:
【発明の名称】タチキニンアンタゴニスト
Document Type and Number:
Japanese Patent JPH10511935
Kind Code:
A
Abstract:
Compounds of formula (I), wherein R1 is mono- or di-substituted phenyl, n is zero or 1, X1 is oxygen, sulfur or =NCN, X2 and X3 are oxygen or sulfur, R2 is hydrogen or methyl, R3 is phenyl, halo-substituted phenyl, 2-naphthyl, IH-indol-3-yl or 1-methyl-indol-3-yl, Z is -N(CH3)- or -CH2-, R4 is phenyl, 3,5-bis(trifluoromethyl)phenyl or pyridyl and R5 is hydrogen, phenyl 3,5-bis(trifluoromethyl)phenyl or pyridyl, whereby, when X3 is sulfur, Z is -N(CH3)- and acid addition salt thereof have tachykinin antagonist activity and are useful as pharmaceuticals, e.g. for the treatment of pain.
Inventors:
Ko, Sue Yang
Walpole, Christopher
Walpole, Christopher
Application Number:
JP51826196A
Publication Date:
November 17, 1998
Filing Date:
December 12, 1995
Export Citation:
Assignee:
Novartis Actien Gezel Shaft
International Classes:
A61P25/04; A61P29/00; C07D401/14; A61K38/00; C07D403/12; C07D411/12; C07K1/113; C07K5/078; (IPC1-7): C07K5/078; A61K38/00; C07K1/113
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)