Title:
【発明の名称】VCAM-1の発現を阻害するためのチオケタール及びチオエーテル
Document Type and Number:
Japanese Patent JP2003528109
Kind Code:
A
Abstract:
Thioketals and thioethers are provided that inhibit the expression of VCAM-1, and which can be used in the treatment of VCAM-1 mediated diseases including inflammatory disorders, cardiovascular diseases, occular diseases, autoimmune diseases, neurological disorders, and cancer. The compounds also can be used to treat hyperlipidemia and/or hypercholesterolemia.
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Inventors:
Men, Chills Kyu
Hung, Lee Kay
Somers, Patricia Kay
Sikorsky, The A's A
Hung, Lee Kay
Somers, Patricia Kay
Sikorsky, The A's A
Application Number:
JP2001568958A
Publication Date:
September 24, 2003
Filing Date:
March 21, 2001
Export Citation:
Assignee:
Aserodynics Incorporated
International Classes:
C07D295/08; A61K31/10; A61K31/145; A61K31/166; A61K31/185; A61K31/192; A61K31/198; A61K31/401; A61K31/4164; A61K31/4402; A61K31/4406; A61K31/505; A61K31/5375; A61K31/662; A61K31/7034; A61K45/00; A61P1/00; A61P1/02; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P11/02; A61P11/06; A61P11/08; A61P13/02; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P17/14; A61P19/02; A61P25/00; A61P25/02; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07C323/20; C07C323/60; C07D207/16; C07D213/30; C07D233/64; C07D239/26; C07H15/203; (IPC1-7): C07D207/16; A61K31/10; A61K31/145; A61K31/166; A61K31/185; A61K31/192; A61K31/198; A61K31/401; A61K31/4164; A61K31/4402; A61K31/4406; A61K31/505; A61K31/5375; A61K31/662; A61K31/7034; A61K45/00; A61P1/00; A61P1/02; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P11/02; A61P11/06; A61P11/08; A61P13/02; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P17/14; A61P19/02; A61P25/00; A61P25/02; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07C323/20; C07D213/30; C07D233/64; C07D239/26; C07D295/08; C07H15/203
Attorney, Agent or Firm:
Yoshio Kawaguchi (4 outside)