Title:
【発明の名称】ストロメリシン開裂産生物を検出する抗体
Document Type and Number:
Japanese Patent JPH08502353
Kind Code:
A
Abstract:
Monospecific antibodies are produced which are specific for fragments of the connective tissue protein aggrecan, generated by specific stromelysin cleavage. These monospecific antibodies are used in an assay system to detect polypeptide fragments of aggrecan, produced by the specific cleavage of aggrecan by stromelysin. The presence of aggrecan polypeptide fragments demonstrates stromelysin activity. Elevations of stromelysin occur in osteoarthritis, rheumatoid arthritis, atherosclerotic lesions, gout, inflammatory bowel disease (IBD), idiopathic pulmonary fibrosis (IPF), certain cancers, joint injuries, and numerous inflammatory diseases. The monospecific antibodies and the assay system are used to quantitate aggrecan polypeptide fragments as a readout of stromelysin activity and to evaluate potential stromelysin inhibitors.
Inventors:
Mumphode, Lithiadee A
Lark, Mitsuiel D'Aburille
Bane, Ellen Bee Kay
Hollner, Rory A
Lark, Mitsuiel D'Aburille
Bane, Ellen Bee Kay
Hollner, Rory A
Application Number:
JP50913794A
Publication Date:
March 12, 1996
Filing Date:
September 21, 1993
Export Citation:
Assignee:
Merck End Company, Inc.
International Classes:
G01N33/53; A61K39/395; A61K49/00; C07K14/47; C07K14/78; C07K16/18; G01N33/573; (IPC1-7): G01N33/573; A61K49/00; C07K16/18; G01N33/53
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)