Title:
【発明の名称】局所的オリゴヌクレオチド療法
Document Type and Number:
Japanese Patent JPH07501204
Kind Code:
A
Abstract:
Disclosed is a method for localized application of antisense oligonucleotides, which has been found to be effective in inhibiting expression and translation of a variety of genes. The method utilizes antisense oligonucleotides which are specific for the mRNA transcribed from the gene of interest. The antisense oligonucleotides are applied directly to the desired locus of the cells to be treated, where they hybridize with the mRNA and inhibit expression of the gene. Devices for localized antisense application and methods for making them also are described.
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Inventors:
Rosenberg, Robert Di.
Simmons, Michelle
Edelman, Eraser
Langer, Robert S.
De Keeser, Jean-Ruck
Simmons, Michelle
Edelman, Eraser
Langer, Robert S.
De Keeser, Jean-Ruck
Application Number:
JP50224092A
Publication Date:
February 09, 1995
Filing Date:
June 23, 1992
Export Citation:
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
International Classes:
A61K31/70; A61K9/00; A61K31/7088; A61K48/00; A61P43/00; C07H21/04; C12N15/00; C12N15/113; C12Q1/68; A61K38/00; (IPC1-7): C12N15/00; A61K31/70; A61K48/00; C07H21/04; C12Q1/68
Attorney, Agent or Firm:
Kiyoya Fujino