Title:
【発明の名称】三環式化合物
Document Type and Number:
Japanese Patent JP2002521449
Kind Code:
A
Abstract:
The novel compounds of the present invention are those of structural formula I: or a pharmaceutically acceptable salt, ester, or stereoisomer thereof, which are inhibitors of 5 alpha -reductase. The compounds of formula I are useful in the oral, systemic, parenteral or topical treatment of hyperandrogenic conditions. Methods of using the compounds of formula I for the treatment of hyperandrogenic conditions such as acne vulgaris, seborrhea, androgenic alopecia, male pattern baldness, female hirsutism, benign prostatic hyperplasia, and the prevention and treatment of prostatic carcinoma, as well as the treatment of prostatitis the treatment of sweat-related conditions such as apocrine gland sweating, hyperhidrosis, and hydradenitis suppurativa, the treatment of polycystic ovary syndrome, the prevention and treatment of bone loss and related diseases, and the prevention and treatment of premature labor are provided, as well as pharmaceutical compositions for the compounds of formula I.
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Inventors:
Huong Langen, Delik
Donald Davour, Graham
Astor, Susan Day
Donald Davour, Graham
Astor, Susan Day
Application Number:
JP2000562021A
Publication Date:
July 16, 2002
Filing Date:
July 26, 1999
Export Citation:
Assignee:
Merck End-Campany Inc.
International Classes:
A61K31/167; A61K31/203; A61K31/473; A61K31/506; A61K31/58; A61K31/585; A61P5/28; A61P13/08; A61P17/00; A61P17/08; A61P17/14; A61P35/00; C07D215/227; C07D221/10; C07D401/12; C07D215/22; (IPC1-7): C07D221/10; A61K31/167; A61K31/203; A61K31/473; A61K31/506; A61K31/58; A61K31/585; A61P5/28; A61P13/08; A61P17/00; A61P17/08; A61P17/14; A61P35/00; C07D401/12
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)