Title:
【発明の名称】細胞接着分子ELAM-1(E-セレクチン)およびLECAM-1(L-セレクチン)のインヒビターとしてのトリテルペノイド酸誘導体
Document Type and Number:
Japanese Patent JPH08504181
Kind Code:
A
Abstract:
Triterpenoid acid derivatives have been found to have structures similar to natural ligands to the extent that these derivatives bind to natural selectin receptors including endothelial leukocyte adhesion molecule-1 (ELAM-1) and leukocyte/endothelial cell adhesion molecule-1 (LECAM-1). The molecules can be administered to the patients by themselves or in pharmaceutical formulations in order to alleviate inflammation and/or treat other abnormalities associated with the excessive binding of leukocytes to endothelial receptors.
Inventors:
Lao, Nala Singa
Anderson, Mark Brian
Nailway, John Jay.
Massa, John Henry
Anderson, Mark Brian
Nailway, John Jay.
Massa, John Henry
Application Number:
JP50755694A
Publication Date:
May 07, 1996
Filing Date:
September 10, 1993
Export Citation:
Assignee:
Glycomed Incorporated
International Classes:
G01N33/53; A61K31/704; A61K49/00; A61K51/00; A61K51/04; A61P29/00; C07H15/18; C07H15/203; C07H15/207; C07H15/24; C07H15/256; C07H17/04; C07J63/00; (IPC1-7): C07J63/00; A61K31/705; A61K49/00; A61K51/00; G01N33/53
Attorney, Agent or Firm:
Shusaku Yamamoto