Title:
【発明の名称】アルファ―V―インテグリン阻害剤としてのチロシン誘導体
Document Type and Number:
Japanese Patent JP2000502664
Kind Code:
A
Abstract:
Disclosed are compounds of formula (I) in which X represents alkylene with 1-6 C atoms or 1,4-piperidyl; Y is absent or represents O, CONH or -CC-; R<1> represents H, CN, N3, NH2, H2N-C(=NH) or H2N-(C=NH)-NH (the primary amino groups can also be provided with conventional amino protective groups); R<2>, R<3> each independently of one another represent H, A, A-SO2-, Ar-SO2, campher-10-SO2-, COOA or a conventional amino protective group; A, R<4> each independently of one another represent H or alkyl with 1-10 C atoms; and Ar represents phenyl or benzyl which is unsubstituted or single-substituted with CH3. Also disclosed are the physiologically tolerable salts of these compounds. The compounds and salts thereof can be used as alpha v-integrin inhibitors, in particular for treating tumours, osteoporoses, osteolytic disorders and for suppressing angiogenesis.
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Inventors:
Diefenbach, Beate
Fitchen, Claus
Gante, Joachim
Goodman, Jimon
Wiesner, Matthias
Friedrich, Lippmann
Fitchen, Claus
Gante, Joachim
Goodman, Jimon
Wiesner, Matthias
Friedrich, Lippmann
Application Number:
JP52328297A
Publication Date:
March 07, 2000
Filing Date:
December 16, 1996
Export Citation:
Assignee:
Merck Patent Gesellschaft Mitt Beschlenktel Haftung
International Classes:
A61K31/00; A61K31/195; A61K31/445; A61K31/4465; A61P5/24; A61P19/00; A61P19/10; A61P35/00; A61P43/00; C07C271/22; C07C271/28; C07C279/08; C07C311/06; C07C311/10; C07D211/46; C07C311/13; C07C311/14; C07C311/19; C07D211/62; (IPC1-7): C07C279/08; A61P5/24; A61P19/10; A61P35/00; A61P43/00; A61K31/195; A61K31/4465; C07C271/22; C07C311/06; C07C311/10; C07C311/13; C07C311/14; C07C311/19; C07D211/46
Attorney, Agent or Firm:
Kiyokazu Kazuwa (1 person outside)