Title:
【発明の名称】ベータ3-アドレナリン受容体アゴニストおよびベータ1およびベータ2-アドレナリン受容体アンタゴニストとして有用なアリールオキシおよびアリールチオプロパノールアミン誘導体、およびその医薬組成物
Document Type and Number:
Japanese Patent JPH10503507
Kind Code:
A
Abstract:
A compound formula (I) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein R<0> represents an aryl group optionally substituted with one, two or three substituents selected from the list consisting of: hydroxy, hydroxymethyl, nitro, amino, alkylamino, dialkylamino, alkylsulphonamido, arylsulphonamido, formamido, halogen, alkoxy and allyl; X represents O or S; R<1> and R<1a> each independently represents hydrogen or an alkyl group; R<2> represents OCH2CO2H, or an ester or amide thereof, or R<2> represents a moiety of formula (b), wherein R<4> represents hydrogen, alkyl, hydroxyalkyl, arylalkyl, aryloxyalkyl, aralkyloxyalkyl or cycloalkyl and R<5> represents hydroxy, alkoxy, arylalkyloxy, hydroxyalkyloxy, alkoxyalkyloxy, aryloxyalkyloxy, arylalkoxyalkyloxy or cycloalkyloxy or R<5> represents hydrogen, alkyl, substituted alkyl, cycloalkyl, aryl, arylalkyl, aryloxyalkyl, arylalkyloxyalkyl or R<5> together with OR<4> represents O(CH2)nO, wherein n is 2, 3 or 4; and R<3> represents hydrogen, halogen, alkyl or alkoxy or R<3> together with R<2> represents a moiety of formula (c) or an ester or amide thereof; providing that 4-[2-[2-hydroxy-3-(4-hydroxyphenoxy)propylamino]propyl]phenoxyacetic acid and salts and esters thereof and the compounds of examples 1 to 36 disclosed in EP0328251 are excluded from the scope of formula (I); a pharmaceutical composition containing such a compound, a process of preparing such a compound and the use of such a compound in medicine.
Inventors:
Bee Ray, Lee James
Thompson, Marvin
Dean, David Kenneth
Kotecha, Nikesh Rasiklar
Barge, John Michael
Ward, robert william
Thompson, Marvin
Dean, David Kenneth
Kotecha, Nikesh Rasiklar
Barge, John Michael
Ward, robert william
Application Number:
JP50619396A
Publication Date:
March 31, 1998
Filing Date:
July 27, 1995
Export Citation:
Assignee:
SmithKline Beecham Public Limited Company
International Classes:
A61K31/195; A61K31/215; A61K31/357; A61K31/36; A61K31/66; A61P1/00; A61P1/04; A61P3/00; A61P3/08; A61P9/10; C07D317/58; A61P25/24; A61P25/26; A61P29/00; A61P43/00; C07C217/30; C07C217/34; C07C311/08; C07C311/21; C07C323/25; C07D317/46; C07F9/30; C07F9/32; C07F9/40; (IPC1-7): C07C217/30; A61K31/195; A61K31/215; A61K31/36; A61K31/66; C07C311/08; C07C311/21; C07C323/25; C07D317/58; C07F9/40
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)
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