Title:
【発明の名称】生化学的に高活性な二環式芳香族化合物とそれを含有する医薬用および化粧品用の組成物
Document Type and Number:
Japanese Patent JP2677542
Kind Code:
B2
Abstract:
Bicyclic aromatic derivs. of formula (I) and their salts and optical and geometric isomers are new. R1 = H, Me, CH2OR6, OR8, COR10 or SOpR12; provided that R1 = OR8 only when R2+R4 form a fused benzene ring; R2 = H, lower alkyl, OH, OR7, OCOR7, amino or NHCOR7; R3 = H or lower alkyl; or R2+R3 = a bond; R4 = H, 1-20C alkyl, OH, OR7 or OCOR7; or R2+R4 forms a fused benzene ring; R5 = H, halo, lower alkyl, NO2, OH, OR7, OCOR7 or NR13R14; X = O, SOt or NR12; Y, Z = CR13R14, O or SOt; provided that not both are SOt or O; R6 = H, lower alkyl or COR7; R7 = lower alkyl; R8 = H, lower alkyl or (CH2)m(CO)nR9; R9 = lower alkyl or heterocyclyl; R10 = H, lower alkyl, OR11 or NR'R''; R11 = H, 1-20C alkyl, alkenyl, mono- or polyhydroxy-alkyl, opt. substd. aryl, opt. substd. aralkyl or a sugar, aminoacid or peptide gp.; R12 = H or lower alkyl; R13, R14 = H or lower alkyl; m = 1-3; n = 0-1; p = 0-3; t = 0-2; R', R'' = H, lower alkyl, mono- or polyhydroxy-alkyl, opt. substd. aryl or an aminoacid or sugar gp.; or NR'R'' = heterocycle; alkyl gps. contain 1-20C; lower = 1-12C.
Inventors:
Jean-Michel Bernardon
Application Number:
JP786396A
Publication Date:
November 17, 1997
Filing Date:
January 19, 1996
Export Citation:
Assignee:
Say Yale de Galderma
International Classes:
A61K8/00; A61K8/30; A61K8/35; A61K8/36; A61K8/368; A61K8/41; A61K8/42; A61K8/44; A61K8/46; A61K8/49; A61K8/60; A61K8/64; A61K31/165; A61K31/19; A61K31/195; A61K31/535; A61K31/5375; A61P9/00; A61P11/00; A61P17/00; A61P27/02; A61P29/00; A61P35/00; C07D295/18; A61P43/00; A61Q5/00; C07C43/215; C07C43/23; C07C43/285; C07C45/29; C07C45/71; C07C47/277; C07C47/575; C07C49/255; C07C49/84; C07C59/72; C07C59/90; C07C65/26; C07C65/40; C07C69/035; C07C69/618; C07C69/734; C07C69/736; C07C69/94; C07C229/68; C07C229/70; C07C233/47; C07C235/66; C07C237/30; C07C317/22; C07C317/44; C07C323/20; C07C323/22; C07C323/60; (IPC1-7): C07C43/285; A61K7/00; A61K7/06; A61K31/165; A61K31/19; A61K31/195; A61K31/535; C07C47/277; C07C49/255; C07C59/90; C07C65/40; C07C69/035; C07C69/618; C07C69/734; C07C229/70; C07C235/66; C07C237/30; C07C317/22; C07C323/20; C07C323/22; C07D295/18
Attorney, Agent or Firm:
Masatake Shiga (2 outside)