Title:
【発明の名称】立体配座的に安定化された細胞付着ペプチド
Document Type and Number:
Japanese Patent JP2547263
Kind Code:
B2
Abstract:
Novel synthetic Arg-Gly-Asp containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformational structure such as a helix, by providing an additional chemical structure such as an amide or an enantiomer of a naturally occurring amino acid, or by other methods. In particular, there are provided cyclic peptides having increased affinity and selectivity for the certain receptors over that of linear, Arg-Gly-Asp-containing synthetic peptides.
Inventors:
PIEERUSHUBATSUHAA MAIKERU DEII
RUOSURAACHI ERITSUKI AI
RUOSURAACHI ERITSUKI AI
Application Number:
JP50064789A
Publication Date:
October 23, 1996
Filing Date:
December 08, 1988
Export Citation:
Assignee:
RA JORA KYANSAA RISAACHI FUAUNDEESHON
International Classes:
B31B50/06; A61L27/00; B65H3/06; B65H7/18; C07K1/02; C07K5/08; C07K5/10; C07K7/06; C07K7/08; C07K7/56; C07K14/00; C07K14/47; C07K14/705; C07K14/78; A61K38/00; (IPC1-7): C07K14/78; C07K1/02
Domestic Patent References:
| JP63215696A | ||||
| JP63218698A | ||||
| JP63225399A | ||||
| JP63179891A |
Other References:
【文献】米国特許4683291(US,A)
【文献】欧州特許出願公開114759(EP,A)
【文献】欧州特許出願公開114759(EP,A)
Attorney, Agent or Firm:
Shusaku Yamamoto