Title:
【発明の名称】二本鎖核酸とのヌクレオチド塩基対-特異的相互作用を受ける環状化合物に関する組成物および方法
Document Type and Number:
Japanese Patent JP2002539077
Kind Code:
A
Abstract:
The design, synthesis, and use of cyclic compounds, including cyclic polyamides, is described. Such compounds comprise at least two polymer portions, one of which comprises at least three molecular units, and the other comprises at least four molecular units. At least one molecular unit of such a compound is a hydrogen bond donor or acceptor. The polymer portions are covalently linked to form a cycle. These compounds are capable of targeting specific nucleotide sequences in double-stranded nucleic acids, particularly double-stranded DNA. Accordingly, such compounds can be used to modulate, e.g., increase or decrease, the expression of one or more genes in vitro or in vivo.
Inventors:
Baird, Eldon Yee.
Durban, Peter Bee.
Durban, Peter Bee.
Application Number:
JP2000592313A
Publication Date:
November 19, 2002
Filing Date:
January 06, 2000
Export Citation:
Assignee:
California Institute of Technology
International Classes:
A61K31/4188; A61K38/00; A61K48/00; A61P31/04; A61P31/12; A61P31/18; A61P35/00; C07D259/00; C07D487/22; C07H19/00; C07H21/02; (IPC1-7): C07D487/22; A61K31/4188; A61K38/00; A61K48/00; A61P31/04; A61P31/12; A61P31/18; A61P35/00; C07D259/00
Foreign References:
| WO1998035702A1 | 1998-08-20 | |||
| WO1998037066A1 | 1998-08-27 | |||
| WO1998037067A1 | 1998-08-27 | |||
| WO1998037087A1 | 1998-08-27 | |||
| WO1998045284A1 | 1998-10-15 | |||
| WO1998049142A1 | 1998-11-05 | |||
| WO1997030975A2 | 1997-08-28 |
Attorney, Agent or Firm:
Hidekazu Miyoshi (1 outside)