Title:
【発明の名称】RNAを調節するための組成物と方法
Document Type and Number:
Japanese Patent JPH07502749
Kind Code:
A
Abstract:
Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.
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Inventors:
Cook, Philip Dunn
Bruce, thomas
Charles John, Guinosso
Kawasaki, Andrew Mamoru
Glyfay, richard
Bruce, thomas
Charles John, Guinosso
Kawasaki, Andrew Mamoru
Glyfay, richard
Application Number:
JP51594693A
Publication Date:
March 23, 1995
Filing Date:
March 05, 1993
Export Citation:
Assignee:
Isis PharmaceuticalsInc
International Classes:
A61K31/70; A61K31/7042; A61K31/7052; A61K31/7056; A61K31/706; A61K31/7064; A61K31/7068; A61K31/7072; A61K31/7076; A61K31/708; A61K31/7088; A61K48/00; A61P31/12; A61P43/00; C07H19/00; C07H19/04; C07H19/052; C07H19/056; C07H19/06; C07H19/10; C07H19/12; C07H19/14; C07H19/16; C07H19/19; C07H19/20; C07H19/23; C07H21/00; C07H21/02; C07H21/04; C07H23/00; C07J43/00; C07K14/16; C12N9/02; C12N15/09; C12N15/113; C12P21/00; C12Q1/68; C12Q1/70; A61K38/00; (IPC1-7): C07H21/02; A61K31/70; A61K48/00; C12Q1/68
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)