Title:
【発明の名称】コンホメーションが固定されたヌクレオシド類縁体
Document Type and Number:
Japanese Patent JP3481945
Kind Code:
B2
Abstract:
Conformationally locked 4',6'-cyclopropane-fused carbocyclic nucleoside analogues. The compounds are prepared by condensing a cyclopropane-fused carbocyclic allylic alcohol with substituted purine or pyrimidine bases. The condensation products are then modified to produce the adenosine, guanosine, cytidine, thymidine and uracil nucleoside analogues. The compounds are therapeutically useful as antimetabolites, or in the preparation of anti-metabolic agents.
Inventors:
Marquez, Victor E.
Rodriguez, Juan Bee.
Nick Rouse, Mark See.
Birch, Joseph Jay. Jr.
Siddiki, McBurray A.
Rodriguez, Juan Bee.
Nick Rouse, Mark See.
Birch, Joseph Jay. Jr.
Siddiki, McBurray A.
Application Number:
JP50996195A
Publication Date:
December 22, 2003
Filing Date:
September 23, 1994
Export Citation:
Assignee:
The Government of the United States of America, Represented by the Secretary, Department of Health and Human Services
International Classes:
A61K31/70; A61K31/7088; A61P31/18; C07D239/46; C07D239/54; C07D473/18; C07D239/26; C07D473/34; C07H19/04; C07H21/00; (IPC1-7): C07D239/26; A61K31/70; A61P31/18; C07D473/18; C07D473/34; C07H21/00
Attorney, Agent or Firm:
Atsushi Nakajima (4 people outside)