Title:
【発明の名称】新ムチンエピトープに対する単クローン性抗体を生成するハイブリドーマ
Document Type and Number:
Japanese Patent JP2597372
Kind Code:
B2
Abstract:
Novel hybridoma cell lines producing monoclonal antibodies reactive with purified mucin antigens from normal and tumor sources are generated using mucins, including purified mucins from tumor sources. Epitopes on mucin antigens from normal and tumor sources are demonstrated to be distinct, using these new antibodies. The antibodies may be useful alone or in combination, in the diagnosis and treatment of cancer including malignancies of the breast and lung.
Inventors:
Peter S Linsley
Diane Horn
Joseph P. Brown
Diane Horn
Joseph P. Brown
Application Number:
JP29164587A
Publication Date:
April 02, 1997
Filing Date:
November 18, 1987
Export Citation:
Assignee:
Oncogen
International Classes:
A61K39/395; C07K14/00; C07K14/005; C07K14/195; C07K16/00; C07K16/30; G01N33/53; C07K19/00; C12N5/00; C12N5/10; C12N15/00; C12N15/02; C12P21/00; C12P21/08; G01N33/574; G01N33/577; A61K38/00; C12R1/91; (IPC1-7): C12P21/08; C07K16/30; C12N15/02; G01N33/53; G01N33/574; G01N33/577
Domestic Patent References:
| JP60253976A |
Other References:
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Ｍｏｌｅｃｕｌａｒ Ｉｍｍｕｎｏｌｏｇｙ，２１［１０］（１９８４）Ｐ．９５５−９６０
Ｐｉｓｅａｓｅ Ｍａｒｋｅｒｓ，４［４］（１９８６）Ｐ．２４７−２５４
Ｍｏｌｅｃｕｌａｒ Ｉｍｍｕｎｏｌｏｇｙ，２１［１０］（１９８４）Ｐ．９５５−９６０
Ｐｉｓｅａｓｅ Ｍａｒｋｅｒｓ，４［４］（１９８６）Ｐ．２４７−２５４
Attorney, Agent or Firm:
Minoru Nakamura (4 outside)