Title:
【発明の名称】ポリマーを引き伸ばす方法および装置
Document Type and Number:
Japanese Patent JP2003507026
Kind Code:
A
Abstract:
The present invention provides structures and methods that allow polymers of any length, including nucleic acids containing entire genomes, to be stretched into a long, linear conformation for further analysis. The present invention also provides structures and methods for selecting and stretching polymers based on their lengths. Polymers are loaded into a device and run through the structures. Stretching is achieved by, e.g., applying shear forces as the polymer passes through the structures, placing obstacles in the path of the polymer, or a combination thereof. Since multiple molecules may be stretched in succession, extremely high throughput screening, e.g., screening of more than one molecule per second, is achieved.
Inventors:
Chang, Eugen, Wai.
Glitch, Lance, Sea.
Wellman, Paris, Es.
Glitch, Lance, Sea.
Wellman, Paris, Es.
Application Number:
JP2001517140A
Publication Date:
February 25, 2003
Filing Date:
August 11, 2000
Export Citation:
Assignee:
US Genomics, Incorporated
International Classes:
B01F5/06; B01L3/00; C12M1/00; C12M1/42; G01N33/50; G01N1/28; G01N37/00; C12Q1/68; C12Q1/6869; G01N33/44; (IPC1-7): C12M1/00; C12M1/42; G01N33/50; G01N37/00
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)