Title:
【発明の名称】2’位に置換された4-メチルビフェニル誘導体の側鎖のブロム化方法
Document Type and Number:
Japanese Patent JP2002542227
Kind Code:
A
Abstract:
A process for preparing 4-bromomethylbiphenyl derivatives substituted in the 2' position of general formula (I) by brominating 4-methylbiphenyl derivatives substituted in the 2' position of general formula (II) wherein: R is CN, COOR1, CONR1R2, or C(OR3)=NR4, or 5-tetrazolyl optionally substituted by benzyl, methyloxycarbonyl, ethyloxycarbonyl, 9-fluorenylmethyloxycarbonyl, 2,2,2-trichloroethyloxycarbonyl, benzyloxycarbonyl, tert-butyloxycarbonyl, allyloxycarbonyl, trichloroacetyl, trifluoroacetyl, or trityl; R1 and R2 which are identical or different are hydrogen or C1-C6-alkyl; R3 and R4 together are a C2-C3-alkylene bridge optionally mono-, di-, tri-, or tetra- substituted by one or more of the groups methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, phenyl, or naphthyl, wherein the brominating is carried out by means of an N-bromoimide or N-bromoamide in a solvent of organic carboxylic acid esters.
Inventors:
Schneider, Heinrich
Application Number:
JP2000612260A
Publication Date:
December 10, 2002
Filing Date:
April 12, 2000
Export Citation:
Assignee:
Boehringer Ingelheim Pharma Comandito Gezelshaft
International Classes:
C07B39/00; C07C63/70; C07C67/287; C07C67/307; C07C69/76; C07C69/78; C07C51/363; C07C253/30; C07C255/50; (IPC1-7): C07C51/363; C07C63/70; C07C67/307; C07C69/76; C07C253/30; C07C255/50
Attorney, Agent or Firm:
Akaoka Mio