Title:
【発明の名称】親水性分子の脂質化のための方法および組成物
Document Type and Number:
Japanese Patent JP2002515883
Kind Code:
A
Abstract:
Fatty acid derivatives of disulfide-containing compounds (for example, disulfide-containing peptides or proteins) comprising fatty acid-conjugated products with a disulfide linkage are employed for delivery of the compounds to mammalian cells. This modification markedly increases the absorption of the compounds by mammalian cells relative to the rate of absorption of the unconjugated compounds, as well as prolonging blood and tissue retention of the compounds. Moreover, the disulfide linkage in the conjugate is quite labile in vivo and thus facilitates intracellular or extracellular release of the intact compounds from the fatty acid moieties.
Inventors:
Shen, Wei Chang
One, Jinhwa
One, Jinhwa
Application Number:
JP51593398A
Publication Date:
May 28, 2002
Filing Date:
September 26, 1997
Export Citation:
Assignee:
University of Southern California
International Classes:
A01N37/18; A61K31/7088; A61K38/00; A61K47/48; A61P43/00; C07C231/00; C07C323/00; C07C323/39; A61K9/127; C07C323/59; C07D213/71; C07D473/18; C07H19/06; C07H19/16; C07H21/00; C07J43/00; C07K1/00; C07K5/093; C07K7/06; C07K14/00; C07K14/485; C07K14/585; C07K14/62; A61K; C07C; (IPC1-7): C07K14/00; A61K9/127; A61K31/7088; A61K38/00; A61K47/48; A61P43/00; C07K7/06; C07K14/485; C07K14/585; C07K14/62
Attorney, Agent or Firm:
Shusaku Yamamoto