Title:
【発明の名称】Moraxella catarrhalisの有用な抗原に関する方法と組成
Document Type and Number:
Japanese Patent JP3499868
Kind Code:
B2
Abstract:
The present disclosure relates to selected antigenic proteins obtained from the outer membranes of Moraxella catarrhalis, that are found to have a variety of useful properties. These proteins, termed OMPs ("Outer Membrane Proteins"), are characterized as having molecular weights of about 30 kD, 80 kD and between about 200 and 700 kD, respectively. Studies set forth herein demonstrated that monoclonal antibodies directed against these proteins confer a protective effect against infection by Moraxella catarrhalis organisms in animal models, demonstrating the potential usefulness of such antibodies in conferring passive immunity as well as the potential usefulness of these OMPs, or variants thereof, in the preparation of vaccines. Also disclosed are DNA segments encoding these OMPs, methods for preparing the antigens or variants, through the application of recombinant DNA techniques, as well as diagnostic methods and embodiments.
Inventors:
Hansen, eric jay
Helminen, Maja
Macaiver, Isobel
Helminen, Maja
Macaiver, Isobel
Application Number:
JP50448193A
Publication Date:
February 23, 2004
Filing Date:
August 14, 1992
Export Citation:
Assignee:
Board Of Regents, The University Of Texas System
International Classes:
A61K39/095; A61K39/02; A61K39/395; A61P31/04; C07K14/195; C07K14/21; C07K16/00; C07K16/12; C12N1/21; C12N15/00; C12N15/02; C12N15/09; C12N15/31; C12P21/00; C12P21/08; G01N33/53; G01N33/569; G01N33/577; A61K38/00; A61K39/00; C12R1/01; C12R1/19; C12R1/91; (IPC1-7): C12P21/00; A61K39/02; A61K39/395; A61P31/04; C07K14/195; C12N1/21; C12N15/09; C12P21/08; G01N33/53; G01N33/569; G01N33/577
Other References:
ＩＮＦＥＣＴＩＯＮ ＡＮＤ ＩＭＭＵＮＩＴＹ（１９８９）Ｖｏｌ．５７，Ｎｏ，１０，ｐ．２９３８−２９４１
Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｉｎｆｅｃｔｉｏｕｓ Ｄｉｓｅａｓｅｓ（１９８８）Ｖｏｌ．１５８，Ｎｏ．４，ｐ．７６１−７６５
Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｉｎｆｅｃｔｉｏｕｓ Ｄｉｓｅａｓｅｓ（１９８８）Ｖｏｌ．１５８，Ｎｏ．４，ｐ．７６１−７６５
Attorney, Agent or Firm:
Nao Okuyama (3 others)