Title:
【発明の名称】カルバペネム中間体の改良合成方法
Document Type and Number:
Japanese Patent JP2002520326
Kind Code:
A
Abstract:
The invention describes an improved process for synthesizing 1-beta-methyl-2-hydroxymethyl substituted carbapenems as key intermediates for the synthesis of anti-MRSA carbapenem antibiotics. The synthesis eliminates the use of BU3SnCH2OH and HMPA, which are toxic substances and not amenable to industrial scale production. The novel intermediates are also within the scope of this invention.The invention relates to the synthesis of a compound of formula 3:wherein R1 represents H or a suitable protecting group for an alcohol; R2 represents H or methyl; and R5 represents a carboxy protecting group as well as the compounds made therein.
Inventors:
The Jenson, Mark S
Yang, Chiang Hoa
Xiao
Wells, Kenneth M
Yasuda Shusho
Yang, Chiang Hoa
Xiao
Wells, Kenneth M
Yasuda Shusho
Application Number:
JP2000559110A
Publication Date:
July 09, 2002
Filing Date:
July 09, 1999
Export Citation:
Assignee:
Merck End-Campany Inc.
International Classes:
C07D477/00; C07D477/02; (IPC1-7): C07D477/00
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)
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