Title:
【発明の名称】脂質濃度を調節するための方法および医薬組成物
Document Type and Number:
Japanese Patent JPH11515025
Kind Code:
A
Abstract:
PCT No. PCT/US96/15854 Sec. 371 Date Apr. 7, 1998 Sec. 102(e) Date Apr. 7, 1998 PCT Filed Oct. 2, 1996 PCT Pub. No. WO97/16184 PCT Pub. Date May 9, 1997The present invention is a combination of an ACAT inhibitor, for example, sulfamic acid, [[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl) phenyl ester, and an HMG-CoA-reductase inhibitor, for example, atorvastatin, effective for lipid regulation. The combination of agents results in a greater reduction in plasma VLDL and LDL cholesterol and increases HDL cholesterol than either alone resulting in a less atherogenic lipoportein profile The combination is useful in the treatment of patents with or at risk of developing ischemic syndromes in order to restore endogenous vascular endothelium-dependent activities.
Inventors:
Bowcan, Thomas M.A.
Application Number:
JP51734297A
Publication Date:
December 21, 1999
Filing Date:
October 02, 1996
Export Citation:
Assignee:
Warner-Lambert Company
International Classes:
A61K31/00; A61K31/18; A61K31/215; A61K31/216; A61K31/22; A61K31/235; A61K31/35; A61K31/351; A61K31/395; A61K31/40; A61K45/00; A61K31/403; A61K31/404; A61K31/41; A61K31/44; A61K45/06; A61P5/36; (IPC1-7): A61K45/00; A61K31/44; A61K31/40; A61K31/395; A61K31/35; A61K31/235; A61K31/22; A61K31/215; A61K31/18; A61K31/00
Attorney, Agent or Firm:
Chika Takagi (1 person outside)