Title:
【発明の名称】9,11-エポキシステロイドの製造法ならびに該方法に有用な中間体
Document Type and Number:
Japanese Patent JP2001509792
Kind Code:
A
Abstract:
Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula Iwherein-A-A- represents the group -CHR4-CHR5- or -CR4=CR5-;R3, R4 and R5 are independently selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano and aryloxy;R1 represents an alpha-oriented lower alkoxycarbonyl or hydroxyalkyl radical;-B-B- represents the group -CHR6-CHR7- or an alpha- or beta-oriented group:where R6 and R7 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy; andR8 and R9 are independently selected from the group consisting of hydrogen, hydroxy, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonylalkyl, alkoxycarbonylalkyl, alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy, or R8 and R9 together comprise a carbocyclic or heterocyclic ring structure, or R8 or R9 together with R6 or comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic D ring.
Inventors:
Ng, John, S.
Riu, Chin
Anderson, Dennis, Kay.
Lawson, John, Pea.
Week Zorek, Joseph
Kunda, Sustain, A.
Retender, Leo, Jay.
Pozzo, Mark, Jay.
Shin, Yuen-Lun, El.
One, Pin, Tee.
Yonan, Edward, Yi.
Weir, Richard, M.
Cowe, Thomas, Earl.
Baez, Gerio, A.
Elb, Bernhard
Riu, Chin
Anderson, Dennis, Kay.
Lawson, John, Pea.
Week Zorek, Joseph
Kunda, Sustain, A.
Retender, Leo, Jay.
Pozzo, Mark, Jay.
Shin, Yuen-Lun, El.
One, Pin, Tee.
Yonan, Edward, Yi.
Weir, Richard, M.
Cowe, Thomas, Earl.
Baez, Gerio, A.
Elb, Bernhard
Application Number:
JP52703298A
Publication Date:
July 24, 2001
Filing Date:
December 11, 1997
Export Citation:
Assignee:
G.D.Searle & Company
International Classes:
C07D301/12; C07J1/00; C07J21/00; C07J31/00; C07J41/00; C07J53/00; C07J71/00; C12P33/00; C12P33/10; (IPC1-7): C07J71/00; C07J1/00; C07J21/00; C07J31/00; C07J41/00; C07J53/00; C12P33/00; C12P33/10
Attorney, Agent or Firm:
Akira Asamura (3 outside)