Title:
【発明の名称】酸化窒素の代謝を調節する方法、これを実現するための組成物(変形物)、及び酸化窒素代謝の修正を必要とする患者の生体に作用するための方法
Document Type and Number:
Japanese Patent JP2003509358
Kind Code:
A
Abstract:
The invention relates to a process of modification of the nitrogen oxides metabolism by means of modification of the micellar catalysis parameters of NO oxidation. According to the invention, the number of phases and/or the volume ratio of the phases and/or the coefficients of distribution of NO and O2 between the phases are modified. The number of phases is modified by using perfluorocarbons, haloid derivatives thereof and perfluoralkylamines with a high coefficient of distribution of NO and O2, which are used as a hydrophobic phase for micellar analysis. The invention also relates to compositions used to vary the output of nitrite, nitrate, nitrosothiols and other oxidation products, whereby said compositions include emulsions of perfluororganic compounds, catalysts and inhibitors of excessive nitrosation, reducers, free radical scavengers and nitrosation targets which modify the balance of the nitrosated biogeneous compounds. The inventive methods for acting on a patient's organism include using such compositions together with variations in temperature and moisture and with traditional drugs. Independent claims in this invention also relate to the use of the known blood replacement substances containing perfluorated compounds and of the steam bath or the sauna in order to accelerate NO oxidation.
Inventors:
Beda, Natalya Vladimirovna
Gordin, Vladimir Alexandrovich
Ned Spasov, Andrei Arturovic
Rafikov, Ruslan Robertovich
Raffikova, Olga Valeryvna
Suntsova, Tatiyana Pavlovna
Gordin, Vladimir Alexandrovich
Ned Spasov, Andrei Arturovic
Rafikov, Ruslan Robertovich
Raffikova, Olga Valeryvna
Suntsova, Tatiyana Pavlovna
Application Number:
JP2001522976A
Publication Date:
March 11, 2003
Filing Date:
September 11, 2000
Export Citation:
Assignee:
Institute Morekrujarnoy Genetiki Roshiskoy Academia Nauk (EMG ER AEN)
International Classes:
C07D339/04; A61K9/00; A61K9/107; A61K31/02; A61K31/07; A61K31/13; A61K31/131; A61K31/16; A61K31/17; A61K31/198; A61K31/325; A61K31/355; A61K31/375; A61K31/385; A61K33/00; A61K33/04; A61K33/06; A61K33/30; A61K33/32; A61K33/34; A61K33/42; A61K38/00; A61K38/02; A61K38/05; A61K38/08; A61K45/00; A61K45/06; A61K47/24; A61K47/26; A61K47/34; A61P7/02; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P17/02; A61P31/04; A61P35/00; C01B21/40; C07D311/72; (IPC1-7): A61K45/00; A61K9/107; A61K31/02; A61K31/07; A61K31/131; A61K31/16; A61K31/17; A61K31/198; A61K31/325; A61K31/355; A61K31/375; A61K31/385; A61K33/00; A61K33/04; A61K33/06; A61K33/30; A61K33/32; A61K33/34; A61K33/42; A61K38/00; A61K47/24; A61K47/26; A61K47/34; A61P7/02; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P17/02; A61P31/04; A61P35/00
Attorney, Agent or Firm:
Takashi Ishida (4 others)