Title:
【発明の名称】受容体複合体がGP130を含むホルモンのスーパーアゴニスト,アンタゴニスト,及びスーパーアンタゴニストを選択するための方法
Document Type and Number:
Japanese Patent JP2643604
Kind Code:
B2
Abstract:
It has been found that the ligands of the group of cytokins similar to Interleukin 6 (IL-6), that is Oncostatin M (OSM), Leukemia Inhibitory Factor (LIF), Ciliary Neurotrophic Factor (CNTF) and Interleukin 11 (IL-11), induce formation of a receptor complex of which the membrane molecule gp 130 is a part. It is thus possible to formulate the hypothesis that two different surfaces of the protein (in this class of hormones), known as site 1 and site 2, bind to two different molecules: site 1 to the specific receptor and site 2 to gp 130. The invention allows the identification of these sites and the isolation of variants having, with respect to the wild hormone, a greater affinity for the specific receptor (superagonists and superantagonists) or affinity for gp 130 reduced or abolished (antagonists and superantagonists). The figure shows the construct pHen DELTA hIL-6 and the production of phasmidic particles that can be used to select agonists of Interleukin 6.
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Inventors:
SAUINO ROTSUKO
RAAMU ARUMIN
KIRIBERUTO GENARO
RAAMU ARUMIN
KIRIBERUTO GENARO
Application Number:
JP50263394A
Publication Date:
August 20, 1997
Filing Date:
June 23, 1994
Export Citation:
Assignee:
ISUCHI* DEI RISERUSHU DEI BAIOROJIA MOREKORARE PII ANJERETSUTEI SPA
International Classes:
C07K14/475; C07K14/52; C07K14/54; G01N33/53; C07K14/705; C07K19/00; C12N15/12; C12N15/18; G01N33/566; G01N33/68; G01N33/74; (IPC1-7): G01N33/53; C07K14/52; G01N33/566
Domestic Patent References:
| JP4502454A | ||||
| JP429997A | ||||
| JP6507715A |
Other References:
Ｃｅｌｌ，６１（１）Ｐ１３−１４，（１９９０）
Attorney, Agent or Firm:
Akira Asamura (3 outside)