Title:
【発明の名称】芳香族o-スルホカルボン酸およびスルホニル尿素の合成法
Document Type and Number:
Japanese Patent JPH10510820
Kind Code:
A
Abstract:
PCT No. PCT/EP95/04865 Sec. 371 Date Jun. 19, 1997 Sec. 102(e) Date Jun. 19, 1997 PCT Filed Dec. 11, 1995 PCT Pub. No. WO96/19443 PCT Pub. Date Jun. 27, 1996The invention relates to a process for the prepn of ortho-sulfocarboxylic acids, which comprises: a) in a first reaction step, diazotizing an aromatic o-aminosulfonic acid in the presence of an acid and nitrite in water, in an organic solvent or in a mixture thereof, to an o-diazonium sulfonate, and, b) in a second reaction step, reacting the o-diazonium sulfonate in the presence of a palladium catalyst in water, in an organic solvent or in a mixture thereof, with carbon monoxide, under overpressure, to an aromatic o-sulfocarboxylic acid. The invention also relates to a process for the preparation of sulfonylureas using o-sulfocarboxylic acids as intermediates. Thus, 4-methoxyaniline-2-sulfonic acid was diazotized and treated with CO to give 97% 4-methoxybenzoic acid 2-sulfonic acid.
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Inventors:
Seagrist, Uras
Mueller, Manfred
Bruni Scholz, Jane
Mueller, Manfred
Bruni Scholz, Jane
Application Number:
JP51947096A
Publication Date:
October 20, 1998
Filing Date:
December 11, 1995
Export Citation:
Assignee:
Novartis Actien Gezel Shaft
International Classes:
B01J23/44; C07B61/00; C07C303/22; C07C309/58; C07D405/12; C07C309/60; C07C309/61; (IPC1-7): C07D405/12; C07C309/58; C07C303/22; C07B61/00; B01J23/44
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)