Title:
【発明の名称】カルバペネム中間体の合成方法、及び製造された化合物
Document Type and Number:
Japanese Patent JP2002518402
Kind Code:
A
Abstract:
A process of synthesizing a carbapenem compound of formula (6) is disclosed, wherein R represents H or methyl, P and P* independently represent H or protecting groups and each R1 is independently selected from: H, halo, OH, OP wherein P is a protecting group, C1-6 alkyl or C1-6 alkyl substituted with 1-3 of halo, OH, OP, NH2, NHC1-4 alkyl or N(C1-4 alkyl)2, comprising reacting a carbapenem of formula (4') with a compound of formula (7), wherein R, R1, P and P* are as previously defined and R2 represents acetate, C(O)OR' or P(O)(OR'')2, wherein R' and R'' independently represent Clot alkyl, benzyl or aryl, in the presence of a catalyst to produce a compound of formula (6).
Inventors:
Humphrey, Guy Earl
Miller, Ross A
Yasuda Shusho
Miller, Ross A
Yasuda Shusho
Application Number:
JP2000554746A
Publication Date:
June 25, 2002
Filing Date:
June 11, 1999
Export Citation:
Assignee:
Merck End-Campany Inc.
International Classes:
C07D477/02; C07D477/14; C07D477/00; C07D519/00; (IPC1-7): C07D477/00
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)