Title:
【発明の名称】アミド又はカルバメート官能基を含有する炭素鎖を11β位置に有する新規の19―ノルステロイド、それらの製造方法及びこの方法の中間体、それらの薬剤としての使用並びにそれらを含有する製薬組成物
Document Type and Number:
Japanese Patent JP3009169
Kind Code:
B2
Abstract:
The invention relates to the compounds (I):
in which A and B are either
where R2 and R'2 are H or alkyl (C1-4), or
where R3 is H or alkyl (C1-4) or acyl, and
- either R17 and R'17 together form a ketone,
- or R17 is hydroxyl or acyloxy and R'17 represents hydrogen, alkyl, alkenyl or alkynyl, these groups being optionally substituted,
- X represents methylene, arylene, CH2-O or arylenoxy,
- Y represents a single bond or aliphatic chain (C1-18) optionally interrupted by one or more arylene(s) or oxygen(s) or optionally oxidised sulphur(s), the chain optionally terminating in an arylene,
- Z represents a single bond or CH2-O, on the understanding that when Y and Z are a single bond, X cannot be methylene or CH2-O,
-RA and RA' represent hydrogen, alkyl optionally substituted with aryl, alkyl or dialkylamino, hydroxyl, halogen or esterified carboxyl, or RA and RA' form, with the nitrogen, a saturated or unsaturated heterocycle optionally containing one or more other hetero atoms and optionally substituted with an alkyl (C1-4), on the understanding that at least one of RA or RA' is not a hydrogen,
to their preparation, to their use as medicaments, to compositions containing them and to the new intermediates obtained.
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Inventors:
Andre Crosne
Lucian Nudelek
Daniel Philibert
Patrick van de veldo
Lucian Nudelek
Daniel Philibert
Patrick van de veldo
Application Number:
JP4138390A
Publication Date:
February 14, 2000
Filing Date:
February 23, 1990
Export Citation:
Assignee:
Hoechst Marion Roussel
International Classes:
A61K31/565; A61P5/00; C07J1/00; C07J41/00; A61K31/56; C07J43/00; (IPC1-7): C07J41/00; A61P5/00; A61K31/56; C07J43/00
Attorney, Agent or Firm:
Motohiro Kurauchi (1 outside)