Title:
【発明の名称】アミド官能基を含有する炭素鎖を11β位置に有する新規の19-ノルステロイド、それらの製造方法、それらの薬剤としての使用及びそれらを含有する製薬組成物
Document Type and Number:
Japanese Patent JP3073803
Kind Code:
B2
Abstract:
The invention relates to the compounds: either n = 1, K = oxygen, R17 = hydroxyl, R'17 = hydrogen, ethynyl, RA = methyl, RA' = isopropyl, butyl, heptafluorobutyl, X = methylene, phenylene or phenyloxy, Y = -(CH2)7; -(CH2)8-; -(CH2)5-C IDENTICAL C-; -(CH2)q-O-CH2-, q = 5 to 7, and -(CH2)5-S-CH2-, or n = 1 or 2, K = oxygen or sulphur, R17 and R'17 = ketone or R17 = hydroxyl or acyloxy and R'17 = hydrogen, alkyl, alkenyl, alkynyl, X = methylene, arylene, CH2-O, arylenoxy or arylenethio, Y = a bond or aliphatic chain optionally interrupted by arylene, oxygen or sulphur, optionally oxidised, and optionally ending with arylene, Z = bond and if Y and Z = bond, X NOTEQUAL CH2 or CH2-O, RA or RA' = hydrogen, alkyl, heterocycle (5 or 6 members) optionally substituted with RA or RA' NOTEQUAL hydrogen, - or n = 2, or K = sulphur, or X = arylenethio, or RA and RA' = heterocycle substituted by aryl or aralkyl, their preparation, their application as medicinal products and pharmaceutical compositions containing them.
Inventors:
Andre Crosne
Francois Neek
Jean-Georges Toiti
Patrick Bande Verde
Francois Neek
Jean-Georges Toiti
Patrick Bande Verde
Application Number:
JP22641091A
Publication Date:
August 07, 2000
Filing Date:
August 13, 1991
Export Citation:
Assignee:
Hoechst Marion Roussel
International Classes:
A61P5/32; A61P35/00; C07J41/00; C07J43/00; C07J63/00; A61K31/56; C07J75/00; (IPC1-7): C07J41/00; A61K31/56; A61P5/32; C07J63/00; C07J75/00
Other References:
【文献】西独国特許出願公開3621024(DE,A1)
【文献】欧州特許出願公開190759(EP,A1)
【文献】仏国特許出願公開2235949(FR,A1)
【文献】欧州特許出願公開190759(EP,A1)
【文献】仏国特許出願公開2235949(FR,A1)
Attorney, Agent or Firm:
Motohiro Kurauchi (1 outside)