Title:
【発明の名称】新規な抗エストロゲンステロイド、ならびに関連の薬学的組成物および使用法
Document Type and Number:
Japanese Patent JP2001525855
Kind Code:
A
Abstract:
Novel and anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependant disorders. Preferred compounds have 1,3,5-estratiene nucleus, and are substituted at the C-17 or C-11 position with a molecular moiety which renders the compounds effective to competitively block the binding of estrogen to its receptor. Particularly preferred compounds are 17-desoxy-1,3,5-estratienes. Therapeutic methods and pharmaceutical compositions are provided as well.
Inventors:
Tanabe, Masato
Peters, Richard H.
Chao, Wan-le
John Lynn
Peters, Richard H.
Chao, Wan-le
John Lynn
Application Number:
JP53517299A
Publication Date:
December 11, 2001
Filing Date:
December 23, 1998
Export Citation:
Assignee:
SRI International
International Classes:
A61K31/56; A61K31/575; A61K31/58; A61P3/06; A61P5/32; A61P11/00; A61P19/10; A61K31/57; A61P35/00; A61P43/00; C07J13/00; C07J41/00; C07J43/00; A61K9/02; (IPC1-7): C07J41/00; A61K31/57; A61K31/58; A61P3/06; A61P11/00; A61P19/10; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Shusaku Yamamoto