Title:
【発明の名称】神経伝達物質放出調節剤としてのグアニジン置換体及びその誘導体ならびに神経伝達物質放出遮断物質を同定するための新規な方法
Document Type and Number:
Japanese Patent JPH06506455
Kind Code:
A
Abstract:
Modulators of neurotransmitter release including substituted guanidines, N''-aminoguanidines, and N,N',N'',N'''-tetra-substituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use of such neurotransmitter release modulators for the treatment or prevention of pathophysiologic conditions characterized by the release of excessive or inappropriate levels of neurotransmitters. Also disclosed are screening assays for compounds which selectively inhibit glutamate release. Also disclosed are methods of blocking voltage sensitive sodium and calcium channels in mammalian nerve cells.
Inventors:
Gordin, Stanley M
Katra Gadda, Sub Barrow
Who, Rain-Yen
Lady N Luxma
Fisher, James Bee
Nup, Andrew Gunit
Margoline, Lee David
Katra Gadda, Sub Barrow
Who, Rain-Yen
Lady N Luxma
Fisher, James Bee
Nup, Andrew Gunit
Margoline, Lee David
Application Number:
JP50727492A
Publication Date:
July 21, 1994
Filing Date:
February 10, 1992
Export Citation:
Assignee:
Cambridge Neuroscience Incorporated
International Classes:
A61K31/15; A61K31/155; A61K31/16; A61K31/17; A61K31/275; A61K31/277; A61K31/34; A61K31/37; A61K31/38; A61K31/381; A61K31/39; A61K31/40; A61K31/403; A61K31/415; A61K31/42; A61K31/421; A61K31/425; A61K31/428; A61K31/44; A61K31/445; A61K31/4453; A61K31/47; A61K31/472; A61K31/495; A61K31/496; A61K31/50; A61K31/505; A61K31/53; A61K31/54; A61K31/655; A61P25/00; A61P25/04; A61P25/08; A61P25/20; C07C279/04; C07C279/16; C07C279/18; C07C279/22; C07C281/16; C07C281/18; C07D209/00; C07D217/22; C07D239/42; C07D241/20; C07D263/48; C07D277/82; C07D333/36; G01N33/58; (IPC1-7): C07C279/16; A61K31/155; A61K31/38; A61K31/40; A61K31/42; A61K31/425; A61K31/47; A61K31/50; A61K31/505; C07C279/04; C07C279/18; C07C279/22; C07D209/00; C07D217/22; C07D239/42; C07D241/20; C07D263/48; C07D277/82; C07D333/36
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)