Title:
【発明の名称】新規かつ強力な最終分化誘発剤及びその使用方法
Document Type and Number:
Japanese Patent JP3083842
Kind Code:
B2
Abstract:
The invention provides compounds, several of which belong to a class having two or more nonpolar components connected by a polar group and having polar groups on the termini of the compound. The invention also concents a method of selectively inducing termini differentiation of neoplastic cells and thereby inhibiting proliferation of such cells which comprises contacting the cells under suitable condition with an amount of the compound effective to selectively induce terminal differentiation. Moreover, the invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells which comprises administering to the patient an amount of the compound effective to selectively induce terminal differentiation of such neoplastic cells, thereby inhibiting their proliferation and suppressing oncogenicity. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and the compound in an amount effective less than an amount which would cause toxicity in the patient.
Inventors:
Marks, Paul A
Rifkind, Richard A
Breslow, Ronald
Jurassic, swing
Rifkind, Richard A
Breslow, Ronald
Jurassic, swing
Application Number:
JP50192491A
Publication Date:
September 04, 2000
Filing Date:
November 14, 1990
Export Citation:
Assignee:
Sloan-Kettering Institute for Cancer Research
The Trustees of Columbia University in the City of New York
The Trustees of Columbia University in the City of New York
International Classes:
A61K31/165; A61K31/22; A61K31/415; A61K31/515; A61K31/16; A61K31/55; A61P35/00; C07C69/34; C07C229/24; C07C233/04; C07C233/05; C07C233/07; C07C233/36; C07C235/20; C07C243/24; C07C243/28; C07C243/38; C07C259/06; C07C259/08; C07C259/10; C07D231/32; C07D231/36; C07D239/60; C07D239/62; C07D243/08; (IPC1-7): C07C259/06; A61K31/165; A61P35/00; C07C259/10
Domestic Patent References:
| JP5955805A | ||||
| JP4500359A |
Other References:
Ｊ．Ｃｈｅｍ．Ｓｏｃ．，Ｐｅｒｋｉｎ Ｔｒａｎｓ．▲Ｉ▼（１９７８）Ｎｏ．９，ｐ．１０６６−１０７６
Ｊ．Ｍｅｄ．Ｃｈｅｍ．，Ｖｏｌ．１３，Ｎｏ．６（１９７０）ｐ．１２３５−１２３７
Ｊ．Ｍｅｄ．Ｃｈｅｍ．，Ｖｏｌ．１３，Ｎｏ．６（１９７０）ｐ．１２３５−１２３７
Attorney, Agent or Firm:
Takehiko Suzue (3 outside)