Title:
【発明の名称】新生内膜形成、再狭窄、および動脈硬化の予防および処置のための薬剤としてのデスアスパラギン酸アンジオテンシンIを使用する薬学的組成物
Document Type and Number:
Japanese Patent JP3336331
Kind Code:
B2
Abstract:
The use of des-Aspartate-angiotensin I (Arg-Val-Tyr-IIe-His-Pro-Phe-His-Leu) as an anti-neointima and anti-arteriosclerotic agent. The compound, given intravenously attenuates the development of neointima formation in balloon catheter-injured carotid arteries of Sprague Dawley rats. The anti-neointima action was dose-dependent and the maximum effect was obtained with a dose of 10 pmoles/day given 2 days pre- and 13 days post-balloon catheterization. When given orally on a chronic basis at a dose of 0.9 mg/kg/day for 47 weeks, the compound significantly attenuates the development of arteriosclerosis in the spontaneously hypertensive rats. The anti-arteriosclerotic action was not blood pressure dependent.
Inventors:
Sim Men Khun
Application Number:
JP30277398A
Publication Date:
October 21, 2002
Filing Date:
October 23, 1998
Export Citation:
Assignee:
National University of Singapore
International Classes:
A61K38/00; A61K31/00; A61K38/08; A61P9/00; A61P9/10; A61P43/00; C07K7/14; (IPC1-7): A61K38/00; A61P9/10
Other References:
【文献】Eur.J.Pharmacol.,Vol.257,R1-R3,1994
【文献】Hypertension,Vol.18,Suppl.4,II-60 - II-64,1991
【文献】Br.Heart J.,Vol.72,Suppl.3,S57-S60,1994
【文献】Hypertension,Vol.18,Suppl.4,II-60 - II-64,1991
【文献】Br.Heart J.,Vol.72,Suppl.3,S57-S60,1994
Attorney, Agent or Firm:
Takehiro Chiba (1 outside)