Title:
【発明の名称】改良された加水分解性を有するポリ酸無水物
Document Type and Number:
Japanese Patent JPH0757797
Kind Code:
B2
Abstract:
Polyanhydrides with uniform distribution of alkyl and aromatic residues are prepared by melt polycondensation or solution polymerization of p-carboxyphenoxyalkanoic acids or p-carboxyphenylalkanoic acids. These polymers are soluble in common organic solvents and have low melting points, generally in the range of 40 DEG -100 DEG C. The polyanhydrides are especially well suited for forming bioerodible matrices in controlled bioactive compound delivery devices. A polymeric matrix formed according to the method described here degrades uniformly during drug release, preventing the wholescale channeling of the bioactive compound into the environment, and eliminating the problem of the presence of the polymer matrix at the site long after drug release. The polymer displays zero-order kinetic degradation profiles over various periods of time (days to months), at a rate useful for controlled drug delivery. Furthermore, a desired degradation rate may be obtained by choosing the appropriate length of the aliphatic moiety.
Inventors:
DAMU ABURAHAMU JEI
RANGAA ROBAATO ESU
RANGAA ROBAATO ESU
Application Number:
JP50686288A
Publication Date:
June 21, 1995
Filing Date:
July 28, 1988
Export Citation:
Assignee:
MASACHUUSETSUTSU INST OBU TEKUNOROJII
International Classes:
A61K9/00; A61K9/20; A61K31/765; A61K47/34; A61P43/00; C08G67/00; C08G67/04; C08L73/00; C08L73/02; (IPC1-7): C08G67/04; A61K9/00; A61K31/765; A61K47/34; C08L73/02
Domestic Patent References:
| JPS63258924A | 1988-10-26 |
Foreign References:
| US3960150A | 1976-06-01 |
Attorney, Agent or Firm:
Shusaku Yamamoto
Next Patent: ポリアミド樹脂