Title:
【発明の名称】プロスタグランジン組成物および男性勃起機能障害の処置法
Document Type and Number:
Japanese Patent JP2003519657
Kind Code:
A
Abstract:
The invention provides methods of treating erectile dysfunction comprising the step of placing within the fossa navicularis of the patient an effective erection-inducing amount of a prostaglandin E1 composition of a semi-solid consistency. The composition comprises prostaglandin E1, a penetration enhancer, a polysaccharide gum, a lipophilic compound, and an acidic buffer system. The penetration enhancer is an alkyl-2-(N,N-disubstituted amino)-alkanoate ester, an (N,N-disubstituted amino)-alkanol alkanoate, or a mixture of these. The lipophilic compound may be an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, or a mixture of these. The composition includes a buffer system capable of providing a buffered pH value for said composition in the range of about 3 to about 7.4.
Inventors:
Jager, James
Buyuktimkin, Nadir
Buyuk Timkin, Selvette
Buyuktimkin, Nadir
Buyuk Timkin, Selvette
Application Number:
JP2001551477A
Publication Date:
June 24, 2003
Filing Date:
January 10, 2001
Export Citation:
Assignee:
NEXMED HOLDINGS INC.
International Classes:
A61K9/00; A61K31/557; A61K31/5575; A61K45/06; A61K47/14; A61K47/18; A61K47/26; A61K47/36; A61P15/10; A61K47/10; A61P43/00; (IPC1-7): A61K31/5575; A61K47/10; A61K47/14; A61K47/18; A61K47/26; A61K47/36; A61P15/10; A61P43/00
Attorney, Agent or Firm:
Hidekazu Miyoshi (1 outside)