Title:
【発明の名称】物質の生体適合性を増強するための自己集合した薄膜コーティング
Document Type and Number:
Japanese Patent JP2003530926
Kind Code:
A
Abstract:
We make a substrate biocompatible by contacting it with a starting material and initiating alternating charge layer electrostatic self-assembly to form a thin film. Starting materials may be poly(vinylpyrrolidone), poly{bis-(carboxylatophenoxy)phosphazene}, poly(methacrylic acid), poly(l-lysine), poly(ethylene glycol), poly(D-glucosamine), poly(l-glutamic acid), poly(diallyldimethylamine), poly(ethylenimine), hydroxy fullerene, long-sidechain fullerene, or other polymers that participate in electrostatic self-assembly. The thin film fabrication advantageously may be at room temperature. A biocompatible thin film that is uniform and homogeneous can be provided. Optionally, ZrO2, Al2O3 or TiO2 nanoclusters also may be used in the film assembly. The film may be used in a drug delivery device or a medical device. The film may be used for tissue engineering. We also provide a biocompatible composition in which are present a plurality of layers electrostatically self-assembled from at least a polymer or fullerene as mentioned. The substrate is not particularly limited, and may be quartz, glass, plastic, metal or ceramic, a material for a bone implant, bioactive glass, polyester or other polymers, plastic or rubber tubing, bandaging material, composite material, insulator material, semi-conductor material, an artificial hip, a pacemaker, a catheter, a stent or other substrates.
Inventors:
Spillman, William Bee Junior
One, unit
Klaus, Richard O
One, unit
Klaus, Richard O
Application Number:
JP2001576197A
Publication Date:
October 21, 2003
Filing Date:
April 13, 2001
Export Citation:
Assignee:
Virginia Tech Intellectual Properties, Inc.
Spillman, William Bee Junior
One, unit
Klaus, Richard O.
Spillman, William Bee Junior
One, unit
Klaus, Richard O.
International Classes:
A61N1/36; A61F2/82; A61L15/00; A61L27/00; A61L27/34; A61L29/00; A61L31/10; A61M1/14; A61M5/14; A61M25/00; B05B5/08; B05C3/09; B05D1/04; B05D1/18; (IPC1-7): A61L27/00; A61L15/00; A61L29/00; A61M1/14; A61M5/14; A61M25/00; A61M29/02; A61N1/36; B05B5/08; B05C3/09; B05D1/04; B05D1/18
Attorney, Agent or Firm:
Tadahiko Ito (2 outside)