Title:
【発明の名称】β-フェニルイソセリン誘導体の立体選択的な製造方法、及びタキサン誘導体類の製造へのその使用
Document Type and Number:
Japanese Patent JPH08502051
Kind Code:
A
Abstract:
PCT No. PCT/FR93/00966 Sec. 371 Date Apr. 5, 1995 Sec. 102(e) Date Apr. 5, 1995 PCT Filed Oct. 4, 1993 PCT Pub. No. WO94/07847 PCT Pub. Date Apr. 14, 1994This invention relates to a method of stereoselective preparation of a derivative of beta -phenylisoserine of formula (I) by the action of an N-carbonyl-benzylimine of formula (II) on an optically active amide of a protected hydroxyacetic acid of formula (III), followed by hydrolysis of the product obtained. In formula (I), (II) or (III), R is an optionally substituted phenyl radical or R1-O, Ar is an optionally substituted aryl radical and G1 is a hydroxy function protection grouping. The product of formula (I) is particularly useful in preparing taxol and Taxotere which have remarkable antitumor properties. (I) ArCHNCOR (II) (III)
Inventors:
Deni, Jean-Noel
Green,andreux
Kanazawa, Alice
Green,andreux
Kanazawa, Alice
Application Number:
JP50878694A
Publication Date:
March 05, 1996
Filing Date:
October 04, 1993
Export Citation:
Assignee:
Loan-Poulin L'Oré Societe Anonym
International Classes:
B01J23/44; C07C235/34; C07C251/28; C07C269/06; C07C271/12; C07C271/16; C07C271/18; C07C271/22; C07D305/14; C07F7/08; C07C233/83; (IPC1-7): C07C235/34; B01J23/44; C07C251/28; C07C269/06; C07C271/16; C07C271/18; C07C271/22; C07D305/14; C07F7/08
Attorney, Agent or Firm:
Heiyoshi Odashima