【発明の名称】不飽和の17β―置換―3―カルボキシステロイド

Japanese Patent JP3226919

B2

The present invention concerns steroidic 5 alpha -reductase inhibitors having the following formula (I) wherein Y is oxygen or sulphur; R is a group: a) -OR4, wherein R4 is hydrogen or a C1-C6 alkyl group; b) wherein each of R5 and R6, independently, is hydrogen or a C1-C6 alkyl group; c) wherein R7 is hydrogen or a C1-C6 alkyl group and W is a group: (i) wherein R8 is a C1-C6 alkyl group, a C5-C6 cycloalkyl group, a C6-C9 cycloalkylalkyl group, a phenyl group or a benzyl group; or (ii) wherein R9 is a C1-C6 alkyl group or a C5-C6 cycloalkyl group; or (iii) wherein R5 and R6 are as defined above; d) wherein each of R10 and R11 is, independently, hydrogen or a C1-C6 alkyl group or taken together with the nitrogen atom to which they are linked form a pentatomic or hexatomic saturated heteromonocyclic ring, optionally containing at least one additional heteroatom selected from oxygen and nitrogen, and n is an integer of 2 to 4; R1 is hydrogen, a C1-C6 alkyl group, a C5-C6 cycloalkyl group, a C6-C9 cycloalkyalkyl group or an aryl group; each of R2 and R3 is, independently, selected from the group consisting of hydrogen, C1-C6 alkyl, C5-C6 cycloalkyl, C6-C9 cycloalkylalkyl and aryl or R2 and R3, taken together with the nitrogen atom to which they are linked, form a pentatomic or hexatomic saturated heteromonocyclic ring, optionally containing at least one additional heteroatom selected from oxygen and nitrogen; and the symbol (----) represents a single or a double bond provided that when it is a double bond the hydrogen in the 5 alpha position doesn't exist and the pharmaceutically acceptable salts thereof. In view of their 5- alpha reductase inhibiting activity the compounds of the invention can be useful for the treatment of androgen dependent conditions.

WO/1995/026731	TREATING CARDIOVASCULAR DISEASE WITH STEROIDAL 5-ALPHA-REDUCTASE INHIBITORS
WO/2018/057624	METHODS AND COMPOSITIONS FOR STIMULATION AND ENHANCEMENT OF REGENERATION OF TISSUES

Panzeri, Acile
Nessie, Marsera
Di Sare, Enrico

JP50978992A

November 12, 2001

May 22, 1992

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Falm Italy Carlo Erba Societa A Responsorabilita Limitata

A61K31/56; A61K31/58; A61P5/24; A61P5/28; A61P13/02; A61P15/00; A61P17/00; A61P17/02; A61K31/565; A61P17/14; A61P35/00; A61P43/00; C07J41/00; C07J43/00; C07J; (IPC1-7): C07J41/00; A61K31/565; A61P5/28; A61P17/02; A61P17/14; A61P35/00; C07J43/00

Hajime Tsukuni (2 outside)

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