Title:
【発明の名称】置換されたヘテロ環化合物およびその製造方法
Document Type and Number:
Japanese Patent JP3234228
Kind Code:
B2
Abstract:
Heterocyclic compounds of formula (I) and their acid addition salts are new. A = (A1) -O-CO-; (A2) -CH2O-CO; (A3) -O-CH2-CO-; (A4) -O-CH2-CH2-; (A5) -N(R1)-CO-; (A6) -N(R1)-CO-CO-; (A7) -N(R1)-CH2-CH2-; or (A8) -O-CH2-; R1 = H or 1-4C alkyl; m = 2 or 3; Ar1 = phenyl opt. substd. by one or more of halo, OH, 1-4C alkyl, 1-4C alkoxy, CF3 or methylene dioxyl; thienyl, benzothienyl, naphthyl, imidazolyl or pyridyl, all opt. substd. by one halo; indolyl opt. N-substd. by 1-4C alkyl or benzyl; or biphenyl; T = -CH2-Z; -CH(C6H5)2, -C(C6H5)3, or, when A = A4, A7 or A8, T may further be -CO-B-Z; B = a direct bond or methylene; Z = opt. substd. mono-, di- or tri-cyclic aromatic or heteroaromatic gp.; Am = a group Am1-Am4; J1 = Ar2-N(R2)-CH, Ar2(CH2)n-C(R3) or R14-C(R3); Ar2 = pyridyl; phenyl opt. substd. by one or more of halo, OH, 1-4C alkyl, 1-4C alkoxy, CF3, NO2, or methylenedioxy; thienyl, pyrimidyl or imidazolyl, all opt. substd. by 1-4C alkyl; R2 = H, 1-7C alkyl, benzyl, formyl or 1-7C alkylcarbonyl; n = 0 or 1; R3 = H, 1-7C alkyl, formyl, 1-7C alkylcarbonyl, CN, -(CH2)q-OH, -(CH2)q-O-(1-7C alkyl), -(CH2)q-OCHO-, -(CH2)q-OCOR17, -(CH2)q-OCONH-(1-7C alkyl), -NR4R5, -(CH2)qNR6C(=W1)R7, -(CH2)qNR6COOR8, -(CH2)qNR6SO2R9, -(CH2)qNR6C(=W1)NR10R11, -CH2-NR12R13, -CH2CH2-NR12R13, -COOH, 1-7C alkoxycarbonyl, -C(=W1)NR10R11, -CH2COOH, 1-7C alkoxycarbonylmethyl, -CH2-C(=W1)NR10R11, -O-CH2CH2-O-R18, -NR6COCOR19, -CO-NR20-NR21R22, or a gp. of formula (i) or (ii), or a double bond; q = 0, 1 or 2; W1 = O or S; R4, R5 = H or 1-7C alkyl, or R5 may further be 3-7C cycloalkyl, methyl, benzyl or phenyl; or NR4R5 = azetidine, pyrrolidine, piperidine, morpholine, thiomorpholine, perhydroazepine, piperazine or 4-(1-4C alkyl)piperazine; R6 = H or 1-7C alkyl; R7 = H, 1-7C alkyl, vinyl, phenyl, benzyl, pyridyl; 3-7C cycloalkyl opt. substd. by methyl(s), furyl, thienyl, pyrrolyl or imidazolyl; or R6+R7 = (CH2)p; p = 3 or 4; R8 = 1-7C alkyl or phenyl; R9 = 1-7C alkyl; amino opt. substd. by 1 or 2, 1-7C alkyl; phenyl opt. substd. by one or more of halo, 1-7C alkyl, 1-7C alkoxy, CF3, OH, carboxy, 1-7C alkoxycarbonyl, 1-7C alkoxycarbonyloxy, CN, NO2, or amino opt. substd. by 1 or 2, 1-7C alkyl; R10, R11 = H or 1-7C alkyl; or R11 may further be 3-7C cycloalkylmethyl, 3-7C cycloalkyl, OH, 1-4C alkoxy, benzyl or phenyl; or NR10R11 = azetidine, pyrrolidine, piperidine, morpholine, thiomorpholine, or perhydroazepine; R12, R13 = H or 1-7C alkyl; or R13 may further be 3-7C cycloalkylmethyl or benzyl; R17 = 1-7C alkyl; or 3-7C cycloalkyl opt. substd. by one or more Me;, phenyl; or pyridyl; R18 = H, 1-7C alkyl, formyl, or 1-7C alkylcarbonyl; R19 = 1-4C alkoxy; R20-R23 = H or 1-7C alkyl; or NR21R22 = pyrrolidine, piperidine or morpholine; R24, R25 = H or 1-7C alkyl; or R25 may further be formyl or 1-7C alkylcarbonyl; R14 = 1-7C alkyl, 3-7C cycloalkyl, and, when R3 = H, R14 may further be -CONR15R16, and when R3 = H, CN, COOH, 1-7C alkoxycarbonyl or -C(=W1)NR10R11 then R14 may be -NR15R16; R15, R16 = 1-7C alkyl; or NR15R16 = azetidine, pyrrolidine, piperidine, morpholine, thiomorpholine, or perhydroazepine; J2 = Ar3N(R2)-CH or Ar3(CH2)n-CH; Ar3 = phenyl opt. substd. by halo, OH, 1-4C alkyl, 1-4C alkoxy, or CF3; Q = 1-6C alkyl or benzyl, this being in the axial or equatorial configuration; and X- = an anion.
Inventors:
Emond-Alto, Xavier
Gloss Litter, Isabel
Prowat, Vincentzo
Ghoul, patrick
Bambreck, Didier
Gloss Litter, Isabel
Prowat, Vincentzo
Ghoul, patrick
Bambreck, Didier
Application Number:
JP52330896A
Publication Date:
December 04, 2001
Filing Date:
January 30, 1996
Export Citation:
Assignee:
Sanofi sante lab
International Classes:
A61K31/38; A61K31/415; A61K31/416; A61K31/439; A61K31/44; A61K31/4427; A61K31/445; A61K31/451; A61K31/495; A61K31/496; C07D265/10; A61K31/535; A61K31/5355; A61K31/5375; A61K31/5377; A61P1/04; A61P1/08; A61P1/12; A61P7/02; A61P9/10; A61P11/00; A61P11/06; A61P13/08; A61P13/10; A61P13/12; A61P17/00; A61P17/06; A61P17/16; A61P19/02; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P27/02; A61P27/16; A61P29/00; A61P35/00; A61P37/08; A61P43/00; C07C215/28; C07C215/30; C07C217/08; C07C219/14; C07C219/22; C07C233/18; C07C255/03; C07C255/36; C07C255/42; C07C255/43; C07C271/20; C07C271/22; C07D209/10; C07D213/28; C07D213/36; C07D231/12; C07D263/10; C07D263/20; C07D263/38; C07D265/30; C07D265/32; C07D309/12; C07D333/10; C07D333/54; C07D401/06; C07D405/12; C07D413/06; C07D413/12; C07D413/14; C07D417/14; C07D453/02; C07D263/00; C07D265/00; C07D309/00; C07D405/00; (IPC1-7): C07D265/10; C07D263/10; C07D263/20; C07D265/30; C07D265/32; C07D401/06; C07D413/06; C07D413/14; C07D453/02
Domestic Patent References:
| JP60136559A |
Other References:
【文献】英国特許1131990(GB,B)
【文献】Khim.Geterotsikl.Soedin,1967,(4),p.611
【文献】Khim.Geterotsikl.Soedin,1967,(4),p.611
Attorney, Agent or Firm:
Takehiko Suzue (4 outside)